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Nat Prod Res. 2018 Sep;32(18):2139-2146. doi: 10.1080/14786419.2017.1367779. Epub 2017 Aug 28.

Ayurvedic preparation of Zingiber officinale Roscoe: effects on cardiac and on smooth muscle parameters.

Author information

1
a Department of Farmacy and Biotecnology , AlmaMater Studiorum- University of Bologna , Bologna , Italy.
2
b Educational Laboratory ex Lolli Hospital, School of Farmacy , Biotechnology and Sport Science , Imola , Italy.

Abstract

The rhizome of the Zingiber officinale Roscoe, a biennial herb growing in South Asia, is commonly known as ginger. Ginger is used in clinical disorders, such as constipation, dyspepsia, diarrhoea, nausea and vomiting and its use is also recommended by the traditional medicine for cardiopathy, high blood pressure, palpitations and as a vasodilator to improve the circulation. The decoction of ginger rhizome is widely used in Ayurvedic medicine. In this papery by high-performance liquid chromatography, we have seen that its main phytomarkers were 6-gingerol, 8-gingerol and 6-shogaol and we report the effects of the decoction of ginger rhizome on cardiovascular parameters and on vascular and intestinal smooth muscle. In our experimental models, the decoction of ginger shows weak negative inotropic and chronotropic intrinsic activities but a significant intrinsic activity on smooth muscle with a potency on ileum is greater than on aorta: EC50 = 0.66 mg/mL versus EC50 = 1.45 mg/mL.

KEYWORDS:

Ayurvedic medicine; Zingiber officinale Roscoe; cardiac parameters; decoction; in vitro assays; smooth muscle parameters

PMID:
28846029
DOI:
10.1080/14786419.2017.1367779
[Indexed for MEDLINE]

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