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Trends Genet. 2017 Oct;33(10):760-769. doi: 10.1016/j.tig.2017.07.010. Epub 2017 Aug 24.

Circadian Clocks and Metabolism: Implications for Microbiome and Aging.

Author information

1
Department of Systems Pharmacology and Translational Therapeutics, ​Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smilow - 10th Floor, Room 122, Building 421, Philadelphia, PA 19104, USA.
2
Department of Systems Pharmacology and Translational Therapeutics, ​Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smilow - 10th Floor, Room 122, Building 421, Philadelphia, PA 19104, USA. Electronic address: garret@exchange.upenn.edu.

Abstract

The circadian clock directs many aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding, out of phase with the light schedule, may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender-specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome, and how they relate to aging.

KEYWORDS:

aging; circadian clock; gender specificity; metabolism; microbiome

PMID:
28844699
PMCID:
PMC5610101
DOI:
10.1016/j.tig.2017.07.010
[Indexed for MEDLINE]
Free PMC Article

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