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N Engl J Med. 2017 Oct 5;377(14):1319-1330. doi: 10.1056/NEJMoa1709118. Epub 2017 Aug 27.

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.

Collaborators (3344)

Aboyans V, Ha J, Keltai K, Lamy A, Liu L, Moayyedi P, Sharma M, Stoerk S, Varigos J, Bhagirath V, Bogaty P, Botto F, Catanese L, Donato Magno J, Fabbri G, Gabizon I, Gosselin G, Halon D, Heldmann M, Lamelas P, Lauw M, Leong Y, Liang D, Lutay Y, Maly M, Mikulik R, Nayar S, Ng K, Perera K, Pirvu O, Ronner E, Sato S, Smyth A, Sokolova E, Wiendl M, Winkelmann B, Yang X, Yufereva Y, Cairns J, Sleight P, DeMets D, Momomura SI, Prins M, Ramsay T, Goto S, Rouleau JL, Schumi J, Thabane L, Casanova A, Bangdiwala S, Deng E, Dyal L, Khatun R, Marsden T, Pogue J, Tang C, Wong G, Yuan F, Aman S, Ariz A, Ashton H, Belanger J, Belanger M, Brettell K, Chandra J, Choppick C, Cisternino D, Cuncins-Hearn A, Di Marino M, Diao L, Dwomoh S, Dykstra A, Galatsis E, Gasic T, Gutierrez J, Hamilton L, Irwin L, Lapensee C, Li A, Lu X, MacRae L, Malik S, Malvestiti A, Mastrangelo J, Maystrenko A, O'Donnell L, Reeh K, Szymkow P, Thomas S, Thrasher D, Tyrwhitt J, White L, Bastone R, Berkowitz S, Dias A, Ho K, Keller L, Lanius V, Lister K, Merten C, Muehlhofer E, Schmidt K, Tasto C, Tsihlias E, Woroniecka-Osio A, Orlandini A, Niemann G, Pascual A, Toscanelli S, Cabezón M, Debaveye B, Meeusen K, Luys C, Broos K, Vandenberghe K, Luyten A, Oliveira GBF, Vila Nova DC, Konishi MYN, Lonn A, Turbide G, Cayer M, Rovito C, Standen D, Li J, Lopez Pico M, Dusek R, Buzalka V, Larsen J, Paucar MJ, Saarinen M, Simon T, Bezault M, Le Lay M, Epstein L, Fajardo-Moser M, Röser C, Putz-Todd G, Scheidemantel F, Poehler D, Renner J, Hargitai A, Doherty AO, Duffy N, Roarty C, Nolan A, Power A, Yuval R, Ben Ari M, Greenblatt S, Marmor Y, Lucci D, Ceseri M, Baldini E, Cipressa L, Miccoli M, Goto M, Yamasowa H, Kajiwara M, Takase D, Ikeguchi K, Matsumoto M, Ishii M, Asai J, Nozaki D, Akatsuka T, Yoshida T, Shahadan S, Md Nasir N, Schut A, Vinck L, van Leeuwen M, Sanchez J, Aquino MR, Mararac T, Benedyk K, Iordache A, Ciobanu A, Rimbas R, Dragoi Galrinho R, Magda S, Mihaila S, Mincu R, Suran B, Cotoban A, Matei L, Kursakov A, Rusnak P, Zakharova A, Demidova E, Commerford A, Lee S, Ju I, Gunolf M, Lorimer A, Parkhomenko L, Johnson J, Anderson J, Norby-Slycord C, Sala J, Sicer M, Rasmussen M, Luciani C, Cartasegna L, Beltrano C, Medek G, Vico M, Lanchiotti P, Martella C, Hominal M, Castoldi M, Casali W, Raimondi S, Hasbani E, Prado A, Paterlini G, Waisman F, Leonard M, Caccavo A, Alarcon V, Zaidman C, Guerlloy F, Vogel D, Imposti H, Dominguez A, Hrabar A, Fernandez A, Schygiel P, Sokn F, Cuneo C, Gutierrez Carrillo N, Martinez G, Luquez H, Costantino M, Ruiz M, Beccetti N, Mackinnon I, Cluigt N, Ahuad Guerrero R, Fanuele M, Campisi V, Costabel J, Romanelli M, Bartolacci I, Echeverria M, Pedrotti M, Montaña O, Camino A, Crespo C, Barbieri M, Lopez Santi R, Tonin H, Heffes R, Gomez Vilamajo O, Vanesio F, Allegrini E, Garcia Duran R, Garcia C, Garcia Duran L, Schiavi L, Mana M, Bordonava A, Rodriguez M, Gutierrez M, Garrido M, Rodriguez C, Ingaramo A, Costamagna O, Almagro S, Gerbaudo C, Pelagagge M, Bustamante Labarta M, Novaretto L, Maldini A, Lopez L, Albisu Di Gennero J, Ibanez Saggia L, Garcia Vilkas A, Alvarez M, Stoermann W, Vita N, Vottero E, Macin S, Cocco M, Onocko M, Dran R, Gimenez C, Cardona M, Guzman L, Guzman P, Martinez D, Sarjanovich R, Huerta C, Scaro G, Cuadrado J, Rodriguez G, Nani S, Guardiani F, Litvak Bruno M, Ceconi G, Chacon C, Casado M, Fernandez Moutin M, Maffei L, Sassone S, Yantorno M, Grinfeld D, Vensentini N, Rolandi F, Fallabrino L, Majul C, Paez O, Visser M, Luciardi H, Mansilla V, Gonzalez Colaso P, Ferre Pacora F, Jure H, Parody M, Espeche E, Whelan A, Boyle A, Collins N, Roberts-Thomson P, Rogers J, Caroll P, Colquhoun D, Williams L, Shaw J, Blombery P, Amerena J, Lee C, Hii C, Royse A, Royse C, Singh B, Selvanayagam J, Jansen S, Thompson P, Lo W, Hammett C, Poulter R, Graves S, Narasimhan S, Van Den Heuvel P, Wollaert B, Sinnaeve P, Fourneau I, Meuris B, Vanassche T, Ector B, Janssens L, Debonnaire P, Vandekerckhove Y, Van de Borne P, Wautrecht J, Motte S, Leroy J, Schroë H, Vrolix M, Ferdinande B, Vranckx P, Benit E, Elegeert I, Lerut P, Wallaert P, Hoffer E, Borgoens P, Dujardin K, Brasil CKOI, Del Monaco MI, Uint L, Pavanello R, Precoma DB, Vianna HS, Abrantes J, Morelli J, Manenti E, Jaeger C, Reis G, Giorgeto FE, França CCB, Quadros TFS, Saraiva J, Costa M, de Camargo O Jr, Marson Lopes M, Silva J, Maia LN, Nakazone MA, Mouco OMCC, Lemos MABT, Hernandes ME, Pântano GS, de Castro JCM, Rossi PRF, Guedes AAM, dos Santos LB, dos Santos FR, Vidotti MH, Zimmermann SL, Rech R, Nunes C, Abib E Jr, Oliveira KLC, Leaes PE, Botelho RV, Navarro ALC, Silva RA, Arantes FBB, Dutra O, Vaz R, Souza WKSB, Souza ASB, Queiroz WCB, Braile M, Ferreira V, Izukawa NM, Prakasan AK, Nicolau JC, Dalçóquio TF, Tanajura LFL, Serrano CV Jr, Hueb WA, Minelli C, Borsetti Neto FA, Nasi LA, Martins SCO, Oliveira LFA, Silva MAV, Ferreira JO, de Carvalho Cantarelli MJ, Tytus R, Pasyk E, Pandey AS, Rowe A, Cha J, Vizel S, Babapulle M, Semelhago L, Saunders K, Haligowski D, Berlingieri J, Nisker W, Kiaii B, Romsa J, Chu M, Nagpal D, Guo R, Mckenzie N, Quantz M, Bhargava R, Bhargava M, Mehta P, Hill L, Heslop W, Fell D, Hess A, Zadra R, Zeman P, Srivamadevan M, Lam A, Tai S, Al-Qoofi F, Spence F, Anderson T, Kieser T, Kidd W, Fedak P, Smith E, Har B, Brown C, Forgie R, Hassan A, Pelletier M, Searles G, Marr D, Bessoudo R, Douglas G, Legare J, Petrella R, Pavlosky W, Ricci J, Galiwango P, Janmohamed A, Kassam S, Mukherjee A, Vijayaraghavan R, Burstein J, D'Mello N, Glanz A, Noiseux N, Stevens LM, Basile F, Prieto I, Normandin L, Helou J, Do QB, Bainey K, Tymchak W, Welsh R, Merali F, Pandith V, Heffernan M, Orfi J, Mcconachie D, Jedrzkiewicz S, Della Siega A, Robinson S, Nadra I, Poirier P, Dagenais F, Voisine P, Mohammadi S, Doyle D, Baillot R, Charbonneau E, Dumont E, Kalavrouziotis D, Perron J, Jacques F, Laflamme M, Brulotte S, Crete M, Degrâce M, Delage F, Grondin F, Lemieux A, Michaud N, Saulnier D, Ross MK, Nguyen M, Harvey R, Daneault B, Hartleib M, Guzman R, Nguyen T, Singal R, Bourgeois R, Landry D, Kamel S, Rupka D, Kuritzky R, Khaykin Y, Phaneuf DC, Desjardins V, Coll X, Huynh T, Pilon C, Mansour S, Lemire F, Kokis A, Potvin J, Campeau J, Audet M, Boulianne M, Dupuis R, Lauzon C, Pruneau G, Senay B, Pichette F, Cieza T, Breton R, Belisle P, Barabas M, Diaz A, Costa R, Absi F, Garand M, Rheault A, Lemay C, Gisbert A, Raymond A, Barrero M, Gagne CE, Rheault P, Pepin-Dubois Y, Johnston J, Mundi A, Cohen G, Shukle P, Baskett R, Hirsch G, Ali I, Stewart K, Fenton J, Pudupakkam S, Willoughby R, Czarnecki W, Roy A, Montigny M, Descarries L, Mayrand H, Comtois H, Essiambre R, Ringuette G, Boutros G, Gendreau R, Pham L, Nguyen V, Nguyen-Thanh HK, Ben-Yedder N, Nawaz S, Fremes S, Moussa F, Shukla D, Labonte R, Jano G, Bobadilla B, Saavedra J, Bahamondes J, Cobos J, Grunberg E, Corbalan R, Verdejo H, Medina M, Vega M, Nahuelpan L, Castañia F, Raffo C, Vargas A, Reyes T, Vargas D, Perez L, Arriagada G, Potthoff S, Godoy J, Stockins B, Larenas G, Quiñinao F, Sepulveda P, Trucco V, Pincetti C, Saavedra S, Silva P, Vejar M, Rodríguez T, Rodriguez J, Tian H, Zhang J, Meng Y, Wu X, Wu Q, Wang Q, Mu Y, Yang J, Wang F, Zhang W, Ke Y, Jiang H, Yin P, Jia K, Chen C, Wang Z, Qi B, Yu L, Feng G, Li L, Jiang L, Wu S, Yu H, Wu Z, Ding R, Liu S, Xu H, Cao H, Bai X, Zheng Y, Liu Z, Sun H, Yang P, Li B, Feng Z, Yang Y, Xu Z, Wu W, Meng Q, Ge J, Dai Y, Yang H, Chen X, Tian X, Shi Y, Hu T, Zhang R, Zhao Q, Quan W, Zhu Y, Zheng Z, Zhang S, Zhao Y, Zhao C, Wang R, Tao L, Hu D, Wang Y, Li J, Fan F, Huang W, Xia X, Fu G, Jiang D, Wang M, Li C, Xu K, Dong Y, Chen Y, Wu D, Wang C, Sun X, Lu S, Zhou X, Kong Y, Zhang B, Sotomayor A, Suarez M, Ripoll D, Herrera O, Accini Mendoza J, Saad Cure C, Reyes M, Vidal T, Donado Beltran P, Hernandez Jaimes E, Castillo H, Rocha C, Forero L, Zarate Bernal D, Vanstrrahle Gonzalez L, Urina Triana M, Quintero A, Ramirez N, Balaguera Mendoza J, Aroca Martinez G, Cotes C, Mercado A, Lastra Percy X, Perez Mayorga M, Rodriguez N, Molina De Salazar D, Perez Agudelo J, Lopez Villegas L, Agudelo Ramos L, Melo Polo M, Esparza Albornoz A, Forero Gomez J, Sanchez Vallejo G, Aristizabal J, Gallego A, Contreras C, Yepez J, Angel Escobar J, Manzur J F, Cohen L, Boneu D, Garcia Lozada H, Barrios L, Celemin C, Diego M, Garcia Ortiz L, Montoya C, Ramirez E, Arcos Palma E, Ceron J, Acosta G, Gomez Mesa J, Velasquez J, Barreto D, Trujillo Dada F, Trujillo Accini F, Cano R, Corredor De La Cruz K, Maria V, Palmera J, Vesga B, Hernandez H, Moreno Silgado G, Aruachan Vesga S, Burgos Martinez E, Quintero Villareal G, Solano Ayazo F, Porto Valiente J, Zidkova E, Krupicka P, Bultas J, Mandysova E, Lubanda J, Horak J, Belohlavek J, Kovarnik T, Gorican K, Rucka D, Smid O, Dostalova G, Skalicka H, Karetova D, Pavlinak V, Kuchynkova S, Marek J, Rob D, Ravlykova K, Prochazka P, Siranec M, Urbanec T, Vareka T, Nesvadbova P, Kaletova M, Indrakova J, Kryza R, Heczko M, Hanak P, Jancar R, Kocurkova L, Marcinek G, Cermak O, Drasnar T, Richter M, Kaspar J, Spinar J, Parenica J, Parenicova I, Schildberger J, Toman O, Ludka O, Poloczek M, Musil V, Miklik R, Labrova R, Lokaj P, Felsoci M, Bocek O, Kanovsky J, Zatocil T, Jerabek P, Matuska J, Jankovic M, Jankovicova H, Tesak M, Sulc D, Svacinova H, Radvan M, Bednar J, Motovska Z, Petr R, Fischerova M, Branny M, Vodzinska A, Cerny J, Indrak J, Sknouril L, Maly J, Vacek T, Prazak O, Broulikova K, Hajsl M, Jarkovsky P, Kamenik L, Kotik I, Krcova E, Sedlon P, Skvaril J, Cernohous M, Kohoutek J, Levcik M, Holek M, Hajdusek P, Foltynova Caisova L, Novak V, Kladivkova M, Slaby J, Houra M, Vojtisek P, Novotny V, Lazarak T, Pliva M, Pirk J, Barciakova L, Jandova R, Adamkova V, Galovcova M, Peterkova L, Turek D, Prochazka J, Belohoubek J, Spinarova L, Panovsky R, Novotny P, Krejci J, Hude P, Ozabalova E, Godava J, Honek T, Kincl V, Benesova M, Buckova J, Canadyova J, Mokracek A, Homza M, Stverka P, Florian J, Lukac B, Polasek R, Kucera P, Seiner J, Karasek J, Coufal Z, Stastny J, Cernicek V, Skalnikova V, Jiresova E, Brat R, Sieja J, Gloger J, Berger P, Prochazkova I, Samlik J, Brtko M, Tuna M, Polansky P, Omran N, Myjavec A, Hrdinova M, Jansky P, Kratochvilova R, Burkert J, Koubek F, Fiala R, Paulasova Schwabova J, Lindner J, Hlubocky J, Spacek M, Marcian P, Hanak V, Pozdisek Z, Lonsky V, Santavy P, Troubil M, Straka Z, Budera P, Fojt R, Talavera D, Tretina M, Nemec P, Orban M, Bedanova H, Wiggers H, Tougaard R, Larsen A, Nielsen H, Mattsson N, Gunnar G, Bruun N, Folke F, Soendergaard K, Koeber L, Frydland M, Fuchs A, Bang L, Houlind K, Olsen M, Soerensen V, Overgaard Andersen U, Dixen U, Refsgaard J, Moeller D, Zeuthen E, Lund J, Soegaard P, Jensen S, Duarte Y, Duarte W, Cáceres S, Pow Chon Long F, Peñaherrera C, Anzules N, Sánchez M, Zuleta I, López J, Villota M, Sánchez H, Perugachi C, Gómez S, Morejón P, Mármol R, Guamán S, Trujillo F, Escobar M, Carrera F, Ponce F, Terán P, Carrasco S, Tuomilehto J, Humaloja K, Lindberg L, Tuomilehto H, Tuominen ML, Kantola I, Juliard J, Feldman L, Ducrocq G, Boulogne C, Petitalot V, Leclercq F, Roubille F, Agullo A, Ferrari E, Chiche O, Moceri P, Boccara F, Charbonnier M, Azeddine B, Ederhy S, Soulat Dufour L, Cohen A, Etienney A, Messas E, Calvalido A, Galloula A, Zarka S, Courtois MC, Mismetti P, Accassat S, Buchmuller A, Moulin N, Bertoletti L, Seffert B, Sevestre M, Samy Modeliar Remond S, Dupas S, Mardyla J, Le Gloan S, Cayla G, Cornillet L, Schmutz L, Motreff P, Souteyrand G, Amonchot A, Barber-Charmoux N, Combaret N, Malcles G, Brenner S, Christa M, Duengen H, Krackhardt F, Bobenko A, Hashemi D, Stellbrink C, Stellbrink E, Köster C, Guerocak O, Bourhaial H, Oumbe Tiam S, Kemala E, Froemke J, Kadel C, Moellinger H, Friedrich K, Rafoud K, Braun-Dullaeus R, Herold J, Ganzer M, Jeserich M, Kimmel S, Haggenmiller S, Schoengart H, Voehringer H, Opitz C, Appel K, Appel S, Utech A, Finger C, Duersch M, Dorsel T, Wistorf N, Grude M, Nikol S, Ueberschaer D, Kast P, Darius H, Sommer S, Girke F, Oeztuerk C, Ranft J, Mikalo A, Schellong S, Voigts B, Mueller C, Jungmair W, Davierwala P, Misfeld M, Bomke K, Akhavuz O, Haensig M, Vorpahl M, Blem A, Langer G, Nover I, Koehler T, Bajnok L, Marton Z, Laszlo Z, Noori E, Veress G, Fogarassy G, Aradi D, Kelemen B, Vertes A, Davidovits Z, Zsary A, Kis E, Hepp T, Koranyi L, Peterfai E, Bezzegh K, Bakai J, Agardi I, Boda Z, Razso K, Poor F, Varallyay Z, Jarai Z, Sallai L, Dudas M, Barton J, Mahmood K, Makki H, McAdam B, Salim T, Murphy A, Crean P, Liddy AM, Mahon N, Khan I, Hassan S, Curtin R, McFadden E, MacNeill B, Kyvelou S, Canavan M, Veerasingam D, Dinneen S, Halabi M, Rosenfeld I, Levinas T, Goldberg A, Khateeb A, Zimlichman R, Ben-Aharon J, Beniashvili A, Betsalel A, Zeltser D, Rogowski O, Mardi T, Rozenbaum Z, Turgeman Y, Or T, Rabkin Y, Klainman E, Halabi S, Halon DA, Katz A, Plaev T, Drogenikov T, Atar S, Kilimnik M, Wishniak A, Merei M, Zvi Y, Nikolsky E, Zukermann R, Petcherski S, Bosi S, Gaitani S, Naldi M, Barbieri A, Faggiano P, Guidetti F, Adamo M, D’Aloia A, Magatelli M, Robba D, Mos L, Vriz O, Sinagra G, Maras P, Doimo S, Cosmi F, D'Orazio S, Oltrona Visconti L, Leonardi S, Vullo E, Sbaffi A, Azzara G, Mauri S, Gianni U, De Matteis C, Campidonico U, Di Pasquale G, Di Niro M, Riva L, Filippini E, Di Biase M, Ieva R, Martone A, Mandorla S, Regni O, Capponi EA, Martinelli S, Bernardinangeli M, Proietti G, Piccinni GC, Gualtieri MR, Gulizia MM, Francese GM, Portale A, Galvani M, Ottani F, Capatano OG, Conficoni E, Longhi S, Bachetti C, Venturi F, Capati E, Morocutti G, Bisceglia T, Fresco C, Baldin MG, Gamba C, Olivieri C, Perna GP, Battistoni I, Marini M, Cirrincione V, Ingrilli F, Kanno T, Ishii Y, Kohmura C, Igawa T, Izawa K, Daida H, Miyauchi K, Shimada K, Ohmura H, Ito S, Okazaki S, Konishi H, Miyazaki T, Hiki M, Kurata T, Suzuki H, Morimoto R, Yokoyama M, Yamamoto T, Okai I, Isoda K, Fujimoto S, Dohi T, Shimada A, Ozaki Y, Watanabe E, Kawai H, Naruse H, Takada K, Okuda K, Okumura M, Ishikawa M, Ohtsuki M, Ohta M, Sarai M, Koshikawa M, Kawai M, Miyagi M, Motoyama S, Matsui S, Ichikawa T, Kato Y, Nagahara Y, Muramatsu T, Hashimoto Y, Hoshino N, Harada M, Yamada A, Yoshiki Y, Motoike Y, Nomura Y, Miyajima K, Takatsu H, Nishimura H, Nagasaka R, Kawada Y, Miyamoto N, Seki K, Inoue A, Higashiue S, Kojima S, Kuroyanagi S, Furuya O, Komooka M, Yamamoto S, Wakabayashi N, Domae H, Ata T, Hashidomi H, Kawahara R, Hosokawa S, Hiasa Y, Otani R, Kishi K, Takahashi T, Yuba K, Miyajima H, Tobetto Y, Yoneda K, Ogura R, Kobayashi H, Takamura T, Enkou K, Ochi Y, Yamada D, Kuramochi T, Misumi K, Iiduka D, Hirose M, Tone K, Taniguchi Y, Ebihara T, Makino M, Yokota M, Nitta M, Udo A, Shimizu S, Fujii K, Iwakura K, Okamura A, Inoue K, Nagai H, Hirao Y, Tanaka K, Tanaka N, Yamasaki T, Oka T, Iwamoto M, Tanaka T, Nakamaru R, Okada M, Takayasu K, Sumiyoshi A, Inoue H, Kitagaki R, Ninomiya Y, Mizutomi K, Koizumi I, Funada A, Tagawa S, Kamide S, Saku K, Ideishi M, Ogawa M, Uehara Y, Iwata A, Nishikawa H, Ike A, Sugihara M, Imaizumi S, Fujimi K, Kawamura A, Sako H, Morito N, Morii J, Fukuda Y, Yahiro E, Matsunaga A, Matsumoto N, Noda K, Shiga Y, Nagata Y, Kimura K, Ebina T, Hibi K, Iwahashi N, Maejima N, Konishi M, Matsushita K, Minamimoto Y, Kawashima C, Nakahashi H, Kimura Y, Takahashi H, Matsuzawa Y, Kirigaya J, Sato R, Kikuchi S, Ogino Y, Kirigaya H, Kashiwase K, Hirata A, Takeda Y, Amiya R, Higuchi Y, Sakaguchi T, Nakano T, Matsusaki N, Suzuki S, Hayashi T, Nakatani S, Koide M, Kobayashi T, Hamanaka Y, Makino N, Sotomi Y, Abe M, Fujieda H, Hashimoto K, Teratani Y, Abe Y, Yokoyama Y, Higashino H, Okuda H, Yamazato M, Noda T, Arai M, Ono K, Hirose T, Iwama M, Warita S, Goto Y, Abe S, Kojima T, Yoshizane T, Tanihata S, Fujii T, Yagasaki H, Miwa H, Ishiguro M, Kato T, Watanabe R, Horio S, Mita T, Hirayama A, Watanabe I, Hiro T, Nakai T, Takayama T, Yoda S, Yajima Y, Okubo K, Okumura Y, Kato M, Fukamachi D, Aizawa Y, Sonoda K, Iida K, Sasaki N, Iso K, Takahashi K, Kougo T, Haruta H, Kurokawa S, Mano H, Nagashima K, Onaka H, Doi H, Hirano N, Okamoto F, Mori K, Ri G, Zushi R, Otsuka K, Inoko M, Haruna T, Nakane E, Miyamoto S, Izumi T, Honjo S, Ikeda H, Wada Y, Funasako M, Hayashi H, Hamasaki A, Sasaki K, Seko Y, Nakasone K, Hanyu M, Iwasaki Y, Iwasaki K, Ayano S, Hirokami M, Omoto Y, Sasaki H, Sato H, Yuda S, Okubo M, Matsuo H, Tsuchiya K, Kawase Y, Miyake T, Kondo H, Hattori A, Kikuchi J, Okamoto S, Hirata T, Kawamura I, Ota H, Omori H, Tanigaki T, Kamiya H, Sobue Y, Komoda T, Akatsuka Y, Yamamoto M, Isegawa K, Takanezawa M, Kataoka C, Imamaki M, Shibata Y, Yasuda K, Shimano M, Ozaki R, Morishita Y, Okabe K, Kondo K, Miura A, Manita M, Tabata K, Asahi T, Mashidori T, Higa N, Nakata M, Himi T, Matsudo Y, Sekine T, Hou K, Tonoike N, Hama Y, Tanaka S, Ge B, Takahara M, Ishimura M, Shikada T, Ueno H, Amemiya H, Hisamatsu Y, Sada K, Sato T, Harada K, Nakamura T, Ako J, Tojo T, Shimohama T, Kishihara J, Ishii S, Fukaya H, Meguro K, Nishino Y, Inoue M, Matsui Y, Omura Y, Kawakami H, Matsuoka H, Oshita A, Seike F, Kondo N, Miyoshi T, Yamada Y, Uchiya T, Kikuchi Y, Koretsune Y, Abe H, Shinouchi K, Nishida H, Yasumura K, Date M, Ueda Y, Iida Y, Idemoto A, Toriyama C, Yokoi K, Mishima T, Yamada T, Fukunami M, Morita T, Furukawa Y, Kawasaki M, Kikuchi A, Tamaki S, Seo M, Shirakawa Y, Ikeda I, Fukuhara E, Kawai T, Kayama K, Kawahira M, Tanabe K, Nakamura J, Shimomura H, Kudo T, Morisaki S, Ogura Y, Chazono N, Onoue Y, Matsumuro Y, Shirakawa T, Nishi M, Kinoshita N, Nakamura R, Miyai N, Ohta K, Sawanishi T, Takahashi A, Hada T, Nakajima S, Taniguchi N, Mizuguchi Y, Takahashi Y, Hashimoto S, Machida M, Hirabayashi K, Morimoto S, Higashino Y, Otsuji S, Takiuchi S, Yabuki M, Hasegawa K, Shishikura D, Ibuki M, Ishibuchi K, Nagayama S, Ishii R, Tamaru H, Yamamoto W, Utsu N, Miyakoshi K, Nakashima D, Tsukuda K, Ueda K, Nakano A, Fukuda T, Ikeda S, Tsuchiya H, Toshima S, Tateno R, Ishikubo T, Suguta M, Nakamura S, Funatsu A, Mizobuchi M, Tanaka M, Nagai T, Hirano S, Hashimoto T, Doi T, Shirasaka A, Takeda S, Sasaki Y, Ohya H, Hosokawa A, Nishina N, Koki B, Ando K, Hiramori S, Soga Y, Tomoi Y, Tohoku S, Shirai S, Hyodo M, Isotani A, Domei T, Kuramitsu S, Morinaga T, Hayashi M, Hiromasa T, Nagae A, Yamaji Y, Nakao K, Sakamoto T, Taguchi E, Tsurugi T, Tanaka Y, Suzuyama H, Koyama J, Nagano M, Okamatsu H, Kodama K, Nakamura M, Horibata Y, Sone M, Tsunemori M, Bando M, Nakayama T, Tanigaito Y, Nomoto M, Sawamura T, Unoki T, Lim CW, Zainal Rashid R, Najme Khir R, Ibrahim KS, Wan Azman WA, Sridhar GS, Watson T, Abu Kassim Z, Mahmood Zuhdi AS, Abdul Hafidz MI, Abu Hassan MR, Wan Rahimi Shah WF, Karthikesan D, Mohd Suan MA, Md Ali SM, Kasim S, Mohd Arshad MK, Ismail JR, Ibrahim ZO, Chua NYL, Abdul Rahim AA, Rusani BI, Yap LB, Zamrin DM, Amir MA, Ismail NI, Mohammad Razi AA, Prins F, Bendermacher P, Burg M, Lok D, van der Sluis A, Martens F, Badings E, Milhous J, van Rossum P, Viergever E, van Hessen M, Willems F, Tjon Joe Gin R, Swart H, Oomen A, Kromhout S, Lauwerijssen I, Daalmans M, Breedveld R, De Vries K, Feenema Aardema M, Hofma S, Van Der Borgh R, van Nes E, Göbel E, Oei F, Dorman H, Bos R, Zoet-Nugteren S, Emans M, Kragten H, Lenderink T, Feld R, Herrman J, Van Bergen P, Gosselink M, Elvan A, Hoekstra E, The S, de Vries R, Zegers E, Oude Ophuis T, Remmen J, Bech J, Kooistra J, Den Hartog F, Oosterhof T, Bartels G, Posma J, Nierop P, Liem A, Van Der Zwaan C, Asselman M, Van Eck J, Gevers R, Van Gorselen E, van Hal J, Terpstra W, Groenemeijer B, Jerzewski A, Hoogslag P, Geertman J, De Groot M, Dijkstra B, Loyola A, Sulit D, Mercado MJ, Rey N, Evangelista L, Abola M, Padua L, Morales D, Palomares E, Abat M, Santos R, Rogelio G, Chua P, Baello R, Del Pilar J, Alianza M, Alcaraz J, Alcaraz L, Ebo G, Guido-Saliot I, Tirador L, Estoce E, Ygpuara M, Cruz J, Anonuevo J, Pitargue A, Janion M, Drewniak Z, Guzik B, Nowak M, Nosal M, Niewiara Ł, Gajos G, Bury K, Czubek U, Misztal M, Grzybczak R, Zalewski J, Kruszelnicka-Kwiatkowska O, Żabówka M, Rynkiewicz A, Grzybowski A, Szałkowski P, Broncel M, Gorzelak P, Możdżan M, Olszewska Banaszczyk M, Szuba A, Tabin M, Chachaj A, Czarnecka D, Terlecki M, Klocek M, Maga P, Coman I, Tarlea M, Ghionea M, Gavrila C, Dimulescu D, Popescu A, Stoicescu C, Vintila V, Mihaila S, Florescu M, Baghilovici Cretu D, Suran M, Mihalcea D, Lungeanu Juravle L, Cinteza M, Calin I, Bicescu G, Vasile Toma N, Udroiu C, Gherghinescu C, Darabont R, Patrascu N, Constantinescu C, Popescu I, Sinescu C, Andrei C, Axente L, Arsenescu C, Statescu C, Ardeleanu I, Anghel L, Benedek I, Benedek T, Kinga P, Banga DK, Bobescu E, Doka B, Dobreanu D, Sirbu V, Rudzik R, Kantor K, Sus I, Gaita D, Maximov D, Brie D, Mosteoru S, Olariu I, Iancu A, Marc M, Hagiu R, Manole V, Molnar A, Dregoesc I, Iliesiu A, Armean P, Parvu I, Deleanu A, Lighezan D, Buzas R, Petrescu L, Nicola R, Dan R, Crisan S, Trasca L, Teodorescu I, Zara O, Tiron T, Tesloianu D, Spiridon M, Vintila M, Baluta M, Chioncel O, Stoica E, Kulcsar I, Antohi L, Strazhesko I, Tkacheva O, Sharashkina N, Pykhtina V, Vasyuk Y, Shkolnik E, Khadzegova A, Sadulaeva I, Ivanova S, Nesterova E, Nesvetov V, Shupenina E, Shcherbak M, Sizova Z, Beloborodova A, Pozdnyakov Y, Tarasov A, Shvedov I, Zabashta S, Ryzhikova I, Barbarash O, Pecherina T, Vatutin M, Inozemceva A, Kazachek Y, Mineeva E, Kupriyanova T, Voevoda M, Gafarov V, Gromova E, Panov D, Voevoda E, Kovalkova N, Ragino Y, Poponina T, Poponina Y, Garganeeva N, Repin A, Vershinina E, Borodina E, Kalashnikova T, Safyanova O, Osipova I, Antropova O, Pyrikova N, Polyakova I, Efremushkina A, Guryanova N, Kiseleva E, Lomteva E, Shtyrova T, Novikova N, Parfenov D, Volovchenko A, Averkov O, Pavlikova E, Vaulina L, Pletnikova I, Mishchenko L, Saranin S, Tsupko I, Kuznetsova N, Zateyshchikov D, Dankovtseva E, Vlazneva Y, Tolokonnikova N, Zhurina M, Zubova E, Aseycheva O, Sigalovich E, Vertkin A, Rodiukova I, Komissarov S, Sokolova R, Ausheva A, Salbieva A, Yusubova A, Isakova S, Hranai M, Obona P, Cisar P, Semetko J, Vanova P, Ferencikova Z, Vykoukalova T, Gaspar L, Caprnda M, Bendzala M, Pella D, Fedacko J, Hatalova K, Drozdakova E, Peter O, Ntsekhe M, De Andrade M, Seedat S, Gani M, Van Zyl L, Naude M, Cronje T, Van Zyl F, Engelbrecht J, Jansen J, Roos J, Makotoko E, Pretorius C, Mirna S, Nell H, Pretorius M, Basson M, Njovane X, Mohamed Z, Pillay T, Dawood S, Horak A, Lloyd E, Hitzeroth J, Mabin T, Abelson M, Klug E, Gebka M, Hellig F, Alison M, Bae J, Kim C, Kim D, Joo S, Park C, Kim Y, Jarnert C, Rydén L, Mooe T, Binsell-Gerdin E, Dellborg M, Torstensson I, Albertsson P, Hiller M, Perers E, Johansson L, Jansson JH, Al-Khalili F, Almroth H, Andersson T, Eriksson Östman M, Pantev E, Utter F, Tengmark BO, Olsson Å, Liu B, Rasmanis G, Wahlgren CM, Thott O, Moccetti T, Rossi MG, Crljenica C, Dovgan N, Skarzhevskyi O, Kozhukhov S, Tseluyko V, Mishchuk N, Kuznetsov I, Semenikhin S, Matviichuk N, Matuzok O, Yakovleva L, Volkov V, Zaprovalna O, Serik S, Riabukha V, Koval O, Kaplan P, Ivanov A, Romanenko S, Skoromna A, Kononenko L, Saprychova L, Lazareva S, Prokhorov O, Vdovychenko V, Bychkov M, Demydova A, Kapustynska O, Bazylevych A, Dutka R, Vlasyuk Z, Shabat M, Rudenko L, Beregova O, Fedtchouk L, Gusak I, Vizir V, Sadomov A, Shkolovoy V, Nasonenko O, Demidenko O, Karpenko O, Ponomarenko K, Oryshych G, Nevolina I, Mitskevych L, Bezuglova S, Kizim S, Todoriuk L, Brodi N, Karpenko L, Malynovsky Y, Fedotov S, Malynovska O, Goydenko O, Miroshnykov S, Rabota I, Koval V, Ohirko O, Khaba U, Storozhuk B, Danylchuk I, Danylchuk A, Gutsuliak R, Cotton J, Luckraz H, Wrigley B, Venkataraman A, Maher A, Moriarty A, McEneaney D, Connolly D, Davis R, Banerjee P, Davey P, Elmahi E, Senior R, Ahmed A, Birdi I, Gedela S, Singh A, Calvert J, Butler M, Donnelly P, Jasinka A, Orr C, Trevelyan J, Routledge H, Carter J, Oxenham H, Peace A, McNeill A, Austin D, Jackson M, Kukreja N, Kotwinski P, Hilton T, Bilizarian S, Srivastava S, Walsh R, Fields R, Portnay E, Gogia H, Deits R, Salacata A, Hunter J, Bacharach J, Shammas N, Suresh D, Gurbel P, Banerjee S, Grena P, Bedwell N, Sloan S, Lupovitch S, Soni A, Gibson K, Pepper D, Sangrigoli R, Mehta R, Patel J, I-Hsuan Tsai P, Gillespie E, Harrison A, Dempsey S, Phillips R, Hamroff G, Hametz C, Black R, Lader E, Kostis J, Bittner V, Mcguinn W, Cheng R, Pal J, Malhotra V, Michaelson S, Vacante M, Mccormick M, Arimie R, Dukkipati R, Camp A, Dagher G, Kosh y N, Culp J, Thew S, Ferraro A, Costello F, Heiman M, Chilton R, Moran M, Adler F, Balingit P, Comerota A, Seiwert A, French W, Vardi G, Singh T, Serota H, Qayyum U, Das S, Harrison R, Vora A, Bakeen F, Omer S, Chandra L, Casaccia G, Tinto J, Sighel C, Giozzi E, Morell Y, Bianchini M, Yossen M, Hoyos M, Venturini C, Merkusa C, Carrique A, Carrique P, Fracaro V, Torres M, Crunger P, Espinosa M, Passarello A, Zaidman M, Ledesma M, Troncoso C, Aviles A, Rodera Vigil S, Vogel M, Takla M, Funosas C, Ferreiro M, Bruno T, Buzzetti C, Lozano J, Alvarez Dámelio A, Bocanera M, Vicente D, Cenci A, Deluca C, Santana R, Ahuad Calvelo A, Alvarez D'Amelio A, Ahuad Calvelo J, Herrero S, Robertson M, Tapia D, Escalante M, Cañas M, Cendali G, Esposito L, Muñiz M, Montaña J, Di Vruno M, Strevezza M, Lopez Santi M, Massei N, Garate V, Perlo D, Campora F, Jakubowski I, Gonzalez Moisello M, Actis M, Schiavi S, Aguirre M, Ceirano C, Zillo M, Yunis M, Berdini A, Gerbaudo R, Berdini J, Palma F, Pinero S, Virulio S, Vitale A, Sosa Flores G, Ibanez Saggia C, Ibanez Saggia D, Roses A, Martinelli C, Vargas L, Galarza Salazan M, Dran P, Tinnirello V, Pelayes S, Bordoni P, Navarro A, Barilati P, Serra R, Nigro A, Cleiman S, Bianchi M, Vallejo M, Ingratta M, Tonelli L, Levantini M, Bonifacio M, Hansen V, Chaieb A, Majul S, Medina F, Gallinotti P, Madariaga T, Andrea G, Blumberg C, Volpe M, Gandur H, Benincasa V, Barreto M, Jure D, Tulloch G, Greenwell D, Forrest N, Nyman E, Mcintosh C, O'May V, Grabek T, Conway B, O’Donoghue M, Brady L, Duroux M, Ratcliffe M, Shone S, Connelly A, Ferreira-Jardim A, Vandernet R, Downes R, Davids F, Teal L, Knight S, Soraghan D, Spence C, Smith K, Tivendale L, Williams Z, O'Connor M, Walker I, Ferguson L, Holiday J, Griffin R, Palethorpe L, Hindom L, Lilwall L, Wadham S, Narasimhan K, Van Extergem P, Joris I, Oreglia M, Jacobs C, Leus W, Robesyn V, Vanheule K, Van Den Bossche K, Albertijn S, Vissers C, Badts G, Vangenechten K, Derycker K, Dejaegher K, De Grande T, De Clippel M, Gayet F, Jorion M, Jourdan A, Tartaglia K, Zwinnen W, Roijakkers I, Van Genechten G, Schoonis A, Bollen J, Janssen A, De Coninck M, Ruell S, Grimonprez A, Bouckaert N, Van Eeckhoutte H, Malmendier D, Massoz M, Jacquet S, Vanhalst E, Casier T, Barroso SL, Tamashiro N, Correa CP, Sehnem EAB, Precoma CB, Pinheiro L, Ruschel KB, dos Reis AL, Santos MS, de Oliveira LOSP, de Carvalho LMG, dos Santos MES, Reis LLF, da Cunha GT, França FF, Bessa SK, Vicente C, Ormundo C, Trama L, Pires NF, Esteves D, Sila OL Jr, Góes NC, Amorin RC, Faria MO, Bucalon EC, Marin LP, Herek L, Araujo VL, Silva AF, Lima F, Gomes CG, Pagnan LG, Novelli CM, Carvalho JKC, Teodoro AR, Zimmermann EMB, Beiersdorf JR, Machado BG, Pedroso FBV, de Vargas T, Peres CS, dos Santos TF, de Souza SF, Luiz RO, Ferreira P, Souza DF, Cunha SMC, de Resende IM, Furtado CCF, Soprane AA, Brum AB, Zorzo JAT, dos Santos JC, Queiroz LB, Barros FE, Vianna CO, Zanateli A, Vieira APZ, Melo G, Zambonin GEC, Paiva P, Viana RMM, Yagihara MM, Takiuti MM, Miyamoto PB, da Silva MF, Borin LA, Chiazzini SML, Fleck N, Batista RF, Cardoso DT, MCamasmie P, Assompção RP, Marques LL, Leung S, Lewis C, Tytus A, Clarus S, Juranics S, Pandey M, Frenette L, Magi A, Nowacki B, Otis J, Fox B, Corke R, Miller B, Rizzo A, Trombetta L, Power P, Richert L, Haligowski R, Macrae C, Kooistra L, Urso C, Fox S, Felbel S, Stafford C, Stata C, Barnabe B, Mehta K, Faul J, Gohel J, Bhakta S, Harwood A, McPherson C, Marucci J, Manasterski L, Veenhuyzen J, Ramadan D, Madden B, Jetha A, Pajevic M, Dube C, Rolfe B, O’Blenis G, Roy L, Dihel C, Butler J, Simmavong K, Bartol C, Bozek B, Hart B, Shier M, Coughlin M, Lamantia C, Lamantia D, Vilag C, Fecteau J, Dionne J, Péloquin G, Hogg N, Welsh S, Weerasingam S, Lantz M, Lounsbury N, Martin E, Mitchell L, Morgen G, Nelson S, Pelzer E, Sorensen S, LeBlanc A, Bourlaud AS, Prémont A, Léger P, Larivière MM, Tremblay H, Bergeron A, Dumont J, Keilani S, Landry P, Deneufbourg I, Breton C, Bilodeau N, Côté M, Dumont F, Dufort L, Marcoux D, David M, Otis R, Parks J, Cepidoza C, Janz W, Weighell W, Yaworski S, Boyd K, Lambert J, Shea-Landry G, Reid K, Thiessen S, Nemtean D, Futers S, Drouin K, Masson C, Arseneault MC, Lachance N, Bergeron C, Boudreault C, Perkins L, Barnett A, Fortin J, Duclos R, Vallières C, Bouchard-Pilote C, Ouimet F, Roberge B, Couture ML, Deshaies D, Bastien A, Chartrand MJ, Gagné NL, Desbiens K, Alarie P, Cassan J, Ducharme Y, Roy D Tapps I, Bolduc H, Laliberté J, Hickey L, Spero M, Bernstein M, Clement J, Pawluch A, Ricci-Bonzey M, Richer J, Vaillancourt J, Ward B, Mostafai Rad P, Oleski L, Karkhanis R, Hartleib V, Poirier R, Hidalgo J, Hernandez C, Obreque C, Quilapi D, Villa F, Iturriaga C, Ferrada M, Navarrete S, Becerra E, Vargas C, Roque C, Alarcon J, Diaz D, Sepulveda M, Villan C, Garcia N, Lara C, Lezana B, Basso N, Torres G, Pasmino C, Gonzalez S, Medina D, Rodriguez T, Guo T, Chen S, Han W, Shi D, Zhang Q, Li W, Cui L, Huang Z, Gong X, Liu D, Tan S, Caicedo L, Rodriguez A, Mejia I, Escalante Ruiz J, Camera Ochoa C, Conrrado Ortega Y, Accini Diaz A, Rodriguez B, Lopez-Lopez J, Di Stefano K, Florez L, Manco T, Rodriguez D, Urina A, De La Hoz L, Almendrales L, Bello O, Urrea Valencia H, Correa Rivera P, Perdomo I, Alzate J, Rivera E, Jimenez, DMoreno N, Guzman A, Betancourt S, Mendoza Marin H, Leyva M, Ortiz M, Marin E, Angie Lorena A, Alvarez Y, Cervantes Hurtado A, Accini Mendoza A, Trujillo Accini M, Eguis B, Del Portillo C, Ortega M, Delgado P, Arciniegas J, Rodriguez L, Melo Sanchez S, Chavera I, Pastrana Mendoza M, Negrette Quintero A, Zidek M, Hajkova D, Rozskowska P, Opavska I, Souckova E, Matuskova E, Kratochvilova T, Pavelec P, Zelenkova V, Dolezalova Z, Márquez M, Moreira D, Zuleta M, Santana G, Coello A, Andrade G, Salazar J, Rivadeneira J, Vaerma J, Lappalainen S, Silvennoinen S, Haaraoja A, Valimaki S, Roine E, Abergel H, Msakni W, Fuentes A, Briday G, David A, Soltani S, Decorps A, Chettouh M, Douillet M, Zamiti-Smondel A, Cuccu L, Salhi N, Helene M, Martin S, Merah A, Daher P, Laurie S, Roussel L, Leperchois C, Delelo E, Thalamy A, Chazot E, Tahirovic E, Watson S, Brettschneider B, Maas M, Euler K, Rahn G, Beissner S, Anuschek V, Tu E, Buerger M, Schemann J, Klinger C, Kurzidim T, Sahbani S, Laszig S, Beilfuss M, Foerster A, Eichinger G, Rupprecht M, Kuehnert J, Wendler-Huelse I, Buelow-Johansen B, Baierlein A, Iselt M, Sievert B, Frommhold R, Wolf T, Hahn M, Schoen B, Acimic C, Ludwig M, Funkat A, Wagner I, Schink M, Calvo-Sanchez D, Felfoldine Feil J, Patakine Sumegi T, Miko-Pauer R, Courcy M, Kelly C, Farrell D, Kirrane C, Hall M, Gilroy E, Kelsey M, Andrew G, Joyce M, Conway S, Duane L, Omer T, Zuker S, Platner N, Saranga H, Kaufman E, Livshitz L, Genin I, Klainman M, Uziel Iunger K, Abitbul A, Fishman B, Greenshtein I, Tubul O, Lasri E, Zvi R, Yablonski A, Helmer Levin L, Lunetto ML, Savoldi D, Fiorini M, Ramani F, Mariottoni B, Rizzotti D, Di Matteo C, Musio S, Pieroni Minciaroli S, Serani S, Aloisi A, Attanasio C, Tricoli M, Giordano V, Andrioli V, Biundo V, Tullio L, Schiff D, Trovarelli P, Chiodi R, Sampaolesi S, Cina MT, Abatello M, De Tora M, Pietrucci F, Pezzetta S, Chiminelli E, Dall’Asta A, Bennati M, Elia A, Bizzoco M, Iaquaniello A, Spigarelli R, Cremonesi C, Gagliardi M, Torricelli L, Ijichi N, Shiraiwa K, Murakami M, Takeshita K, Sato M, Shiratori A, Kinjo K, Tomita K, Mizuno M, Kurihara F, Tachibana M, Nitta Y, Unno K, Hiramatsu H, Sano A, Nanatsumura M, Tanikawa I, Uesugi K, Banno S, Miyata T, Kujuji A, Kawai K, Maegawa A, Koseki T, Watanabe Y, Aoki S, Maesawa M, Suzuki A, Itose Y, Konishi K, Fujieda K, Nakade S, Minami M, Yoneda J, Akiyama R, Sakai S, Nakatani K, Yamazaki A, Funama M, Kaneko E, Morii S, Onishi M, Sone A, Sagawa N, Iwai F, Kawahara A, Hasimoto C, Ueki M, Kamiji M, Ando M, Yokoo M, Okada Y, Yamada H, Matsushige N, Nagato A, Matsumoto R, Nishikawa M, Oka I, Kitou S, Tachiuchi M, Nakagawa M, Yoneda S, Iwasa K, Matsuda J, Oda A, Tokudome S, Kaneyuki Y, Higaki M, Yoneda H, Kajita C, Suwa K, Sato E, Nagata T, Kubo Y, Umesu A, Ohashi K, Takeuchi M, Tanaka I, Nobehara T, Yamano R, Yumiba A, Hamada M, Nishihata T, Ohashi Y, Morita M, Endo M, Matsugi M, Tateishi H, Nakamori R, Yamashita Y, Okabe M, Matsuo M, Ono T, Shigeyama Y, Ichiyanagi M, Sugimori K, Ohmura C, Igarashi M, Aotsuka S, Komoda N, Watanabe M, Enomoto Y, Suzuki Y, Kawaguchi A, Kasahara A, Koide A, Sakatani T, Kurihara T, Yokota S, Futagi R, Amemiya Y, Ono E, Maeda A, Kadono K, Ishiguchi Y, Kikuchi R, Kuramatsu M, Nakamura E, Chiba S, Higa A, Kitahashi M, Tanaka H, Ito T, Oba M, Tsubouchi M, Toshima M, Morishita M, Miyano A, Kondo M, Watanabe K, Shibata R, Tosaki Y, Ito Y, Saoda M, Yamasaki E, Kadosaki S, Motooka S, Akiyoshi H, Morio S, Nemoto H, Yoshizawa S, Okabe N, Semba K, Yoshida A, Lee Y, Yoshida M, Iwashita Y, Takeda A, Maezato M, Kawahira K, Yoshikawa M, Okamoto N, Nishimura M, Matsuura K, Fukunaga M, Fukai K, Osakabe Y, Yamamura K, Koike M, Shibuya S, Shiramata M, Ono Y, Tsujimoto Y, Tadokoro T, Morishita N, Matsuo Y, Yumoto I, Sakazaki S, Atarashi A, Nabata Y, Okuda N, Fujita A, Matsuo A, Ishizawa Y, Shibata H, Ootsuka M, Taimatsu R, Takeuchi A, Sumi Y, Yamamoto F, Araki Y, Tanaka A, Kuroda S, Sakata R, Okada N, Sawada Y, Miyata M, Asayama H, Koga N, Miki T, Yamaguchi N, Hashimoto A, Fukuike C, Kubo A, Yamasaki M, Mori Y, Nakayama S, Kobayashi Y, Takenaka S, Mashima M, Katsuta H, Matsumura T, Yanagida S, Watanabe N, Kodama S, Kusano M, Yamamoto N, Kamada R, Suzuki K, Itami K, Hasebe Y, Fujita N, Kubota S, Usuki A, Okamoto M, Uno S, Chikuma A, Kishikawa H, Yano K Nakano C, Otaguro M, Kayashima Y, Shinoda M, Jaafar SM, Baharuddin S, Gembor J, Ahmad H, Syed Mansor SM, Abdullah WM, Shafie Z, Muhamad Yunus S, Alwi SM, Hussin N, Basri NA, Ling Ling L, Naem NS, Rutten R, Rademaker H, Van Buijsen M, Scholten M, Stuij S, van Zeijst M, van Houwelingen K, Engelen W, Kramer H, Maassen E, Verhoeven P, Awater J, Terwisscha van Scheltinga C, Meijlis P, Blom L, Bos M, van der Wal M, Van Laerhoven G, Jacobs T, Tan-Urgert B, Van de Gaag J, Den Boer P, Verlek E, Lardinois R, Coenjaerds C, Hendrick R, Schoep J, Froma E, van Nes C, Beuving D, Krikken J, Drent I, Geerlings F, Buvelot S, Wissenburg A, Dijkshoorn A, van Setten van der Meer L, Singerling M, Van Wijk D, Bor A, Aukema-Wouda Z, Hendriks-van Woerden M, Kort I, Danse I, van der Knaap M, de Jong C, Temminck M, Schaefer T, Van der Ven N, Drost I, Mulder R, De Vos A, de Hoop M, Post G, Wielandt D, Edorot N, De Castro K, Flotildes M, Mulingtapang T, Vasquez S, Facundo S, Peralta M, Jose M, Bandiez J, Sulit P, Joaquin F, Arbis MG, Silva C, Delgado D, De Leon R, Maglasang P, Sian A, Alagban C, Alcorano J, Marcelo MJ, Dela Pena C, Hyra I, Malkiewicz B, Mosakowska K, Cana I, Dobrin I, Lautaru A, Manescu G, Samoila N, Lacatus M, Apostoie A, Prunoiu M, Tilinca M, Budeanu A, Nedelcu C, Dumitrache N, Boeru L, Zhuravleva E, Gundova M, Hoffmannova J, Svitkova M, Pekarova T, Ujacka K, Zsoriova T, Kubincova K, Jankovicova Z, Talliard C, Tyumbu N, Mngoma N, Kannemeyer M, Mostert J, Page A, Krahenbuhl C, Tredoux C, Hendricks L, Oliver S, Le Grange M, Naidoo V, Bae Y, Kim H, Lee J, Yu N, An S, Kim E, Yang K, Woo J, Kim S, Rasck J, Smetana S, Ajax K, Bylander L, Lindberg A, Dellborg H, Hultsberg-Olsson G, Harsmar K, Knutsson A, Håkansson L, Kåveryd-Holmström M, Lundmark LM, Norrfors B, Löf P, Skoglund K, Torgersruud M, Johansson K, Mattsson A, Quist M, Haglund P, Lundell L, Gunvasdotter S, Rangman B, Liu R, Shi J, Förstedt G, Nylund L, Welin-Berger B, Nilsson O, Garcia-Värlid A, Forlenza R, Kaminska K, Nagorna T, Cottam V, Harper R, Gilchrist M, Musanhu R, Mackin A, Turner A, Willetts S, Cadd A, Evans J, Young G, Sevillano A, Brodie K, Eccles A, Kelly S, Doughty A, Gray J, Gibson M, Finlayson M, Domingo D, Brazee L, Renaud K, Doman A, Meyer R, Beatty J, Morgan T, Rodas E, Campbell D, Mcquarrie M, Battistelli E, Eisenbraun P, Farley R, Park H, Dwyer J, Adams K, Schneider W, Barbour C, Whyne E, Budzinski S, Craig M, Gilley Elmore J, Scott D, Bellini S, Pepper M, Gunderson K, Stipek I, Schwarz L, Watkins K, Moore V, Palao A, Keane-Richmond P, Franklin L, Ward L, Kostedt G, Bailey S, Hollenweger L, Solomon A, Johnson D, Gloer K, Meyer M, Boleyn M, Nieters D, Humphrey K, Bohn A, Mueller G, Mckenzie H, Edwards T, Velky J, Cole C, Diederick M, Burg S, Coulson T, Karunaratne K, Gunasekera R, Cook S, Fisher S, Garrison K, Passey L, Kuykendall K, Luck K, Ramia, Joan H, Reynoso F, Farley M, Shuman S, Santana-Fernandes E, Ventimiglia A, Steele V, Gers L, Brown P, Wilson J, Freebersyser J, Reno M, Buettner N, Mcgovern M, Hubbard T, Elmore H, Payne D, Mccann M, Decker S, Sharp A, Forgey E, Broussard E, Juett U, Siddiqui A.

Abstract

BACKGROUND:

We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention.

METHODS:

In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months.

RESULTS:

The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=-4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group.

CONCLUSIONS:

Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events. (Funded by Bayer; COMPASS ClinicalTrials.gov number, NCT01776424 .).

PMID:
28844192
DOI:
10.1056/NEJMoa1709118
[Indexed for MEDLINE]

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