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Neurotox Res. 2018 Feb;33(2):353-361. doi: 10.1007/s12640-017-9797-7. Epub 2017 Aug 26.

The Role of HINT1 in Methamphetamine-Induced Conditioned Place Preference.

Li JP1,2, Liu P1, Lei G1, Chu Z1, Liu F1,3, Shi CF4, Dang YH5,6,7, Chen T8,9,10.

Author information

1
College of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, People's Republic of China.
2
Institute of law, Northwest University of Political Science and Law, Xi'an, Shaanxi, People's Republic of China.
3
Affiliated Stomatology Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
4
Institute of Material Evidence Identification, Kaifeng Municipal Public Security Bureau, Kaifeng, Henan, People's Republic of China.
5
College of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, People's Republic of China. psydyh@mail.xjtu.edu.cn.
6
Key Laboratory of the Health Ministry for Forensic Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. psydyh@mail.xjtu.edu.cn.
7
Key Laboratory of Forensic Medicine of Shaanxi Province, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China. psydyh@mail.xjtu.edu.cn.
8
College of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, People's Republic of China. chenteng@mail.xjtu.edu.cn.
9
Key Laboratory of the Health Ministry for Forensic Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. chenteng@mail.xjtu.edu.cn.
10
Key Laboratory of Forensic Medicine of Shaanxi Province, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China. chenteng@mail.xjtu.edu.cn.

Abstract

Drug addiction is a chronically relapsing disorder in humans; yet, the underlying mechanism remained unclear. Recent studies suggested that the histidine triad nucleotide binding protein 1 (HINT1) may play significant roles in diverse neuropsychiatric diseases including drug addiction. In our present study, we used different batches of mice to establish the different stages of methamphetamine (METH)-induced conditioned place preference (CPP) to explore the dynamic changes throughout the process of addiction in different brain regions, including prefrontal cortex (PFC), nucleus accumbens (NAc), corpus striatum (CPu), and hippocampus (Hip). We found that in NAc of the METH group mice, the HINT1 expression level initially increased after acquisition phases, and then dropped to the normal level after extinction phase, and again increased after reinstatement phase. However, there was no statistical difference in the HINT1 expression level in other three encephalic regions (PFC, CPu, and Hip). Therefore, the HINT1 protein, particularly in the NAc, plays a vital role in the METH-induced CPP. However, the precise mechanisms will require further investigation.

KEYWORDS:

Conditioned place preference; HINT1; Methamphetamine

PMID:
28844119
DOI:
10.1007/s12640-017-9797-7
[Indexed for MEDLINE]

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