Polymorphic DNA marker on X chromosome and manic depression

Lancet. 1987 May 30;1(8544):1230-2. doi: 10.1016/s0140-6736(87)92685-7.

Abstract

Heredity is an important factor in vulnerability to manic depression. A genetic linkage has been demonstrated between manic depression and coagulation factor IX at Xq27 with a TaqI polymorphism at the F9 locus in DNA samples from peripheral leucocytes of manic depressive probands and relatives in 10 informative families. Statistical analysis of the pedigrees gave a maximum lod score of 3.10 at a recombination fraction of 0.11, demonstrating a linkage between a manic depressive locus and the F9 locus in the Xq27 region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / genetics*
  • Chromosome Mapping
  • DNA / analysis*
  • Factor IX / genetics
  • Female
  • Genetic Linkage
  • Humans
  • Male
  • Pedigree
  • Polymorphism, Genetic*
  • X Chromosome*

Substances

  • Factor IX
  • DNA