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J Affect Disord. 2018 Jan 1;225:302-305. doi: 10.1016/j.jad.2017.08.047. Epub 2017 Aug 18.

Association between hypovitaminosis D and cognitive inhibition impairment during major depression episode.

Author information

1
McGill University & Douglas Mental Health Research Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada; Pôle de psychiatrie, Assistance Publique Hôpitaux de Marseille, Marseille, France.
2
UPRES EA 2646, Angers University, Angers, France; University Memory Clinic, Angers University Hospital, Angers, France; Department of Neurosciences, Aging, Medicines and Society; Division of Geriatric Medicine, Research Center on Aging and Longevity, Angers University Hospital, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada.
3
CISSS des Laurentides, St-Jerome, Quebec, Canada; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.
4
Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada; Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Centre of Excellence on Aging and Chronic Diseases of McGill integrated University Health Network, Quebec, Canada.
5
McGill University & Douglas Mental Health Research Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada.
6
McGill University & Douglas Mental Health Research Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada; Department of psychiatry, CHU de Nîmes, France.
7
McGill University & Douglas Mental Health Research Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada; UPRES EA 2646, Angers University, Angers, France; CISSS des Laurentides, St-Jerome, Quebec, Canada. Electronic address: richarddevantoy@orange.fr.

Abstract

BACKGROUND:

Major depressive episode (MDE) has been associated with cognitive functioning alteration and hypovitaminosis D (hypoVD), but the relationship between hypoVD, depression, and cognition is not well understood. We aimed to compare patient with MDE with or without hypoVD in regard of cognitive functioning.

METHODS:

91 patients (38.5 years old, 65.9% female) with MDE were included in a cross-sectional study and were evaluated with a complete cognitive battery. None of the participants were medicated at the time of the inclusion. Serum 25-hydroxyvitamin D was measured using LC-MS/MS method, and hypovitaminosis was defined as 25OHD < 50nmol/L. Covariates were gender, season of dosage, first MDE onset, age, body mass index and depression severity RESULTS: Patients with hypoVD demonstrated a higher stroop intereference index time underscoring that means low cognitive inhibition ability. Mutiple logistic regression confirmed that hypoVD was significantly associated with high stroop interference time index after controlling by gender, season of dosage, first MDE onset, age, body mass index and depression severity.

CONCLUSION:

Our results suggest that patient with MDE having hypoVD may be more prone to cognitive impairment.

KEYWORDS:

Cognitive inhibition; Depression; Stroop; Vitamin D

PMID:
28843080
DOI:
10.1016/j.jad.2017.08.047
[Indexed for MEDLINE]

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