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Environ Toxicol Pharmacol. 2017 Oct;55:81-86. doi: 10.1016/j.etap.2017.08.014. Epub 2017 Aug 18.

Long non-coding RNAs: The novel diagnostic biomarkers for leukemia.

Author information

1
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 820916850@qq.com.
2
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 761144287@qq.com.
3
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 332316599@qq.com.
4
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 2426098439@qq.com.
5
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 617804879@qq.com.
6
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 693727611@qq.com.
7
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 1585803559@qq.com.
8
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: 412143030@qq.com.
9
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: zhlh426@163.com.
10
Huizhou Prevention and Treatment Centre for Occupational Disease, Huizhou, 516000, China. Electronic address: 13902659363@163.com.
11
Huizhou Prevention and Treatment Centre for Occupational Disease, Huizhou, 516000, China. Electronic address: 437892987@qq.com.
12
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: xiaoym@mail.sysu.edu.cn.
13
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: wenchen1107@163.com.
14
Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address: thw@gdmu.edu.cn.

Abstract

Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt-100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs may not only useful as biomarkers for the diagnosis and clinical typing and prognosis of cancers, but also as potential targets for novel therapies. Differential expression of lncRNAs has been found in leukemia in the last two years, however, the majority of the lncRNAs described here are transcripts of unknown function and their role in leukemogenesis is still unclear. Here, we summarize the lncRNAs associated with leukemia in order to find a potential classification tool for leukemia, and a new field of research is being explored.

KEYWORDS:

Biomarkers; Classification tool; Leukemia; Long non-coding RNA

PMID:
28841440
DOI:
10.1016/j.etap.2017.08.014
[Indexed for MEDLINE]

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