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Obesity (Silver Spring). 2017 Nov;25(11):1916-1920. doi: 10.1002/oby.21943. Epub 2017 Aug 25.

Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women.

Author information

1
Department of Medicine, Cancer Center, Boston University School of Medicine, Boston, Massachusetts, USA.
2
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
3
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
4
Slone Epidemiology Center, Boston University, Boston, Massachusetts, USA.

Abstract

OBJECTIVE:

The principal objective of this investigation was to identify novel cytokine associations with BMI and type 2 diabetes (T2D).

METHODS:

Cytokines were profiled from African American women with obesity who donated plasma to the Komen Tissue Bank. Multiplex bead arrays of analytes were used to quantify 88 cytokines and chemokines in association with clinical diagnoses of metabolic health. Regression models were generated after elimination of outliers.

RESULTS:

Among women with obesity, T2D was associated with breast adipocyte hypertrophy and with six plasma analytes, including four chemokines (chemokine [C-C motif] ligand 2, chemokine [C-C motif] ligand 16, chemokine [C-X-C motif] ligand 1, and chemokine [C-X-C motif] ligand 16) and two growth factors (interleukin 2 and epidermal growth factor). In addition, three analytes were associated with obesity independently of diabetes: interleukin 4, soluble CD40 ligand, and chemokine (C-C motif) ligand 3.

CONCLUSIONS:

Profiling of inflammatory cytokines combined with measures of BMI may produce a more personalized risk assessment for obesity-associated disease in African American women.

PMID:
28840653
PMCID:
PMC5669048
DOI:
10.1002/oby.21943
[Indexed for MEDLINE]
Free PMC Article

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