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Neurosurg Rev. 2019 Mar;42(1):59-71. doi: 10.1007/s10143-017-0897-x. Epub 2017 Aug 24.

Pathogenesis of peri-tumoral edema in intracranial meningiomas.

Author information

1
Skull Base Surgery Unit, Department of Neurosurgery B, University Hospital of Lyon, Hospices Civils de Lyon, Lyon, France. berhouma.moncef@gmail.com.
2
Laboratory CREATIS - CNRS UMR5220 - INSERM U1206 - Lyon 1 University - INSA, Lyon, France. berhouma.moncef@gmail.com.
3
Skull Base Surgery Unit, Department of Neurosurgery B, University Hospital of Lyon, Hospices Civils de Lyon, Lyon, France.
4
Laboratory CREATIS - CNRS UMR5220 - INSERM U1206 - Lyon 1 University - INSA, Lyon, France.
5
Department of Imaging, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France.

Abstract

Peri-tumoral edema in intracranial meningiomas occurs frequently and obviously impacts the morbidity and mortality of these predominantly benign neoplasms. Several causative factors (age, gender, volume, location…) have been unsuccessfully investigated. Despite recent progresses in metabolic imaging and molecular biology, the pathogenesis of peri-tumoral edema remains debated. Hypotheses include vascular endothelial growth factor, metalloproteinases and interleukins among many others. It is probable that this pathogenesis encompasses all these factors with different levels. The current review aims to shed the light on the investigated factors involved in the pathogenesis of peri-tumoral edema in meningiomas and identify the potential therapeutic targets.

KEYWORDS:

Aquaporins; Cytotoxic edema; Hypoxia-inducible factor; Interleukins; Mast cells; Meningioma; Metalloproteinases; Peri-tumoral brain edema; Vascular endothelial growth factor; Vasogenic edema

PMID:
28840371
DOI:
10.1007/s10143-017-0897-x
[Indexed for MEDLINE]

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