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Cell Mol Life Sci. 2018 Feb;75(3):467-484. doi: 10.1007/s00018-017-2626-6. Epub 2017 Aug 24.

Interaction and cross-talk between non-coding RNAs.

Author information

1
Department of Urology, University of California, San Francisco, San Francisco, CA, USA. soichiro.yamamura@ucsf.edu.
2
San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. soichiro.yamamura@ucsf.edu.
3
Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
4
San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.

Abstract

Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each other through their biding sites. Interactions of miRNAs and lncRNAs have been reported to trigger decay of the targeted lncRNAs and have important roles in target gene regulation. These interactions form complicated and intertwined networks. Certain lncRNAs encode miRNAs and small nucleolar RNAs (snoRNAs), and may regulate expression of these small RNAs as precursors. SnoRNAs have also been reported to be precursors for PIWI-interacting RNAs (piRNAs) and thus may regulate the piRNAs as a precursor. These miRNAs and piRNAs target messenger RNAs (mRNAs) and regulate gene expression. In this review, we will present and discuss these interactions, cross-talk, and co-regulation of ncRNAs and gene regulation due to these interactions.

KEYWORDS:

Circular RNA; Competing endogenous RNA; Interaction; Long non-coding RNA; MicroRNA; PIWI-interacting RNAs; Small nucleolar RNA

PMID:
28840253
PMCID:
PMC5765200
DOI:
10.1007/s00018-017-2626-6
[Indexed for MEDLINE]
Free PMC Article

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