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Theranostics. 2017 Jul 22;7(12):2996-3006. doi: 10.7150/thno.18459. eCollection 2017.

Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring β-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer's Disease.

Li M1,2, Guan Y1,2, Zhao A1,2, Ren J1, Qu X1.

Author information

1
Laboratory of Chemical Biology, State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
2
University of Chinese Academy of Sciences, Beijing 100039, China.

Abstract

Development of sensitive detectors of Aβ aggregates and effective inhibitors of Aβ aggregation are of diagnostic importance and therapeutic implications for Alzheimer's disease (AD) treatment. Herein, a novel strategy has been presented by self-assembly of peptide conjugated Au nanorods (AuP) as multifunctional Aβ fibrillization detectors and inhibitors. Our design combines the unique high NIR absorption property of AuNRs with two known Aβ inhibitors, Aβ15-20 and polyoxometalates (POMs). The synthesized AuP can effectively inhibit Aβ aggregation and dissociate amyloid deposits with NIR irradiation both in buffer and in mice cerebrospinal fluid (CSF), and protect cells from Aβ-related toxicity upon NIR irradiation. In addition, with the shape and size-dependent optical properties, the nanorods can also act as effective diagnostic probes to sensitively detect the Aβ aggregates. This is the first report to integrate 3 segments, an Aβ-targeting element, a reporter and inhibitors, in one drug delivery system for AD treatment.

KEYWORDS:

Alzheimer's Disease.; Au nanorod; Aβ detectors; Aβ inhibitors; Photothermal treatment; Polyoxometalates

PMID:
28839459
PMCID:
PMC5566101
DOI:
10.7150/thno.18459
[Indexed for MEDLINE]
Free PMC Article

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