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Trends Cell Biol. 2017 Nov;27(11):833-850. doi: 10.1016/j.tcb.2017.07.006. Epub 2017 Aug 30.

Emerging Roles for the Lysosome in Lipid Metabolism.

Author information

1
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California, Berkeley, Berkeley, CA 94720, USA.
2
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rzoncu@berkeley.edu.

Abstract

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the crossroads of this network due to its ability to process and sort exogenous and endogenous lipids. The lipid-sorting function of the lysosome is intimately connected to its recently discovered role as a metabolic command-and-control center, which relays multiple nutrient cues to the master growth regulator, mechanistic target of rapamycin complex (mTORC)1 kinase. In turn, mTORC1 potently drives anabolic processes, including de novo lipid synthesis, while inhibiting lipid catabolism. Here, we describe the dual role of the lysosome in lipid transport and biogenesis, and we discuss how integration of these two processes may play important roles both in normal physiology and in disease.

KEYWORDS:

cholesterol; lipid metabolism; lysosome; mTORC1; membrane contact sites

PMID:
28838620
PMCID:
PMC5653458
DOI:
10.1016/j.tcb.2017.07.006
[Indexed for MEDLINE]
Free PMC Article

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