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Gastroenterol Clin North Am. 2017 Sep;46(3):661-677. doi: 10.1016/j.gtc.2017.05.010.

The Evolution of Treatment Paradigms in Crohn's Disease: Beyond Better Drugs.

Author information

1
Department of Medicine, University of Western Ontario, 100 Dundas Street, Suite 200, London, Ontario N6A 5B6, Canada.
2
Department of Medicine, University of Western Ontario, 100 Dundas Street, Suite 200, London, Ontario N6A 5B6, Canada; Department of Epidemiology & Biostatistics, University of Western Ontario, 100 Dundas Street, Suite 200, London, Ontario N6A 5B6, Canada.
3
Department of Medicine, University of Western Ontario, 100 Dundas Street, Suite 200, London, Ontario N6A 5B6, Canada; Department of Epidemiology & Biostatistics, University of Western Ontario, 100 Dundas Street, Suite 200, London, Ontario N6A 5B6, Canada. Electronic address: brian.feagan@robartsinc.com.

Abstract

Despite advances in care, most patients with Crohn's disease (CD) develop complications, such as fistulas, or require surgery. Given the recent advances in drug therapy, an opportunity exists to optimize the management of this chronic disease through early use of effective therapies, clear definition of treatment targets, and application of the principles of personalized medicine. In this article, the authors discuss the evolution of treatment algorithms for CD to incorporate these strategies.

KEYWORDS:

Crohn's disease; Therapy; Treat to target; Treatment algorithms; Treatment paradigms

PMID:
28838421
DOI:
10.1016/j.gtc.2017.05.010
[Indexed for MEDLINE]

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