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Nat Chem. 2017 Sep;9(9):843-849. doi: 10.1038/nchem.2759. Epub 2017 Apr 10.

Chelation and stabilization of berkelium in oxidation state +IV.

Author information

1
Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
2
Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
3
Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
4
J. Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, 18223 Prague 8, Czech Republic.
5
Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Abstract

Berkelium (Bk) has been predicted to be the only transplutonium element able to exhibit both +III and +IV oxidation states in solution, but evidence of a stable oxidized Bk chelate has so far remained elusive. Here we describe the stabilization of the heaviest 4+ ion of the periodic table, under mild aqueous conditions, using a siderophore derivative. The resulting Bk(IV) complex exhibits luminescence via sensitization through an intramolecular antenna effect. This neutral Bk(IV) coordination compound is not sequestered by the protein siderocalin-a mammalian metal transporter-in contrast to the negatively charged species obtained with neighbouring trivalent actinides americium, curium and californium (Cf). The corresponding Cf(III)-ligand-protein ternary adduct was characterized by X-ray diffraction analysis. Combined with theoretical predictions, these data add significant insight to the field of transplutonium chemistry, and may lead to innovative Bk separation and purification processes.

PMID:
28837177
DOI:
10.1038/nchem.2759
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