Format

Send to

Choose Destination
Nature. 1987 Apr 30-May 6;326(6116):840-5.

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands.

Abstract

A genomic sequence close to the cystic fibrosis locus with the characteristics of an HTF island has been selectively cloned and characterized. Two markers flanking this sequence, which is conserved throughout mammalian evolution, show a very much greater disequilibrium than that found with any existing marker. A single mutational event accounts for most cases of cystic fibrosis. The sequence is expressed, and is a candidate for the cystic fibrosis gene.

PMID:
2883581
DOI:
10.1038/326840a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center