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J Am Heart Assoc. 2017 Aug 23;6(9). pii: e006053. doi: 10.1161/JAHA.117.006053.

A Brain Phenotype for Stressor-Evoked Blood Pressure Reactivity.

Author information

1
Department of Psychology, University of Pittsburgh, Pittsburgh, PA gianaros@pitt.edu.
2
Center for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA.
3
Department of Psychology, University of Pittsburgh, Pittsburgh, PA.
4
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA.
5
Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA.
6
Departments of Psychology and Psychiatry, University of Pittsburgh, Pittsburgh, PA.
7
Departments of Psychology and Neuroscience, University of Colorado at Boulder, CO.

Abstract

BACKGROUND:

Individuals who exhibit large-magnitude blood pressure (BP) reactions to acute psychological stressors are at risk for hypertension and premature death by cardiovascular disease. This study tested whether a multivariate pattern of stressor-evoked brain activity could reliably predict individual differences in BP reactivity, providing novel evidence for a candidate neurophysiological source of stress-related cardiovascular risk.

METHODS AND RESULTS:

Community-dwelling adults (N=310; 30-51 years; 153 women) underwent functional magnetic resonance imaging with concurrent BP monitoring while completing a standardized battery of stressor tasks. Across individuals, the battery evoked an increase systolic and diastolic BP relative to a nonstressor baseline period (M ∆systolic BP/∆diastolic BP=4.3/1.9 mm Hg [95% confidence interval=3.7-5.0/1.4-2.3 mm Hg]). Using cross-validation and machine learning approaches, including dimensionality reduction and linear shrinkage models, a multivariate pattern of stressor-evoked functional magnetic resonance imaging activity was identified in a training subsample (N=206). This multivariate pattern reliably predicted both systolic BP (r=0.32; P<0.005) and diastolic BP (r=0.25; P<0.01) reactivity in an independent subsample used for testing and replication (N=104). Brain areas encompassed by the pattern that were strongly predictive included those implicated in psychological stressor processing and cardiovascular responding through autonomic pathways, including the medial prefrontal cortex, anterior cingulate cortex, and insula.

CONCLUSIONS:

A novel multivariate pattern of stressor-evoked brain activity may comprise a phenotype that partly accounts for individual differences in BP reactivity, a stress-related cardiovascular risk factor.

KEYWORDS:

cardiovascular reactivity; functional magnetic resonance imaging; machine learning; mental stress; psychology and behavior; stress

PMID:
28835356
PMCID:
PMC5634271
DOI:
10.1161/JAHA.117.006053
[Indexed for MEDLINE]
Free PMC Article

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