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BMC Res Notes. 2017 Aug 23;10(1):421. doi: 10.1186/s13104-017-2737-z.

Low plasma vitamin A concentration is associated with tuberculosis in Moroccan population: a preliminary case control study.

Author information

1
Unité Mixte de Recherche Nutrition et Alimentation, (CNESTEN-Université Ibn Tofaïl), CNESTEN BP 1382 RP, 10001, Rabat, Morocco.
2
Laboratoire de Biochimie-Immunologie, Faculté des Sciences, Rabat, Morocco.
3
Service de Pneumo-Phtisiologie, Hospital Moulay Youssef, CHU Rabat, Rabat, Morocco.
4
Unité Mixte de Recherche Nutrition et Alimentation, (CNESTEN-Université Ibn Tofaïl), CNESTEN BP 1382 RP, 10001, Rabat, Morocco. mzibri@yahoo.com.

Abstract

BACKGROUND:

Vitamin A plays numerous roles in immune system. Its deficiency alters both the innate and adaptive immunity. Previous results reported that the micronutrients deficiency, particularly vitamin A, is observed in patients with tuberculosis. Thus, we aimed in this study to assess vitamin A concentrations in Moroccan patients with tuberculosis to set up a large efficacy study of vitamin A supplementation for TB infected patients. Plasma retinol concentration was measured by HPLC in 44 recently diagnosed TB patients and 40 healthy controls.

RESULTS:

We showed that plasma vitamin A is significantly lower in tuberculosis patients as compared to healthy controls (p < 0.0001). Moreover, no significant association was found between vitamin A deficiency and, TB severity and patients' ages.

CONCLUSION:

Our study confirms the association between low vitamin A levels and tuberculosis disease.

KEYWORDS:

Deficiency; Morocco; Plasma; Tuberculosis; Vitamin A

PMID:
28835282
PMCID:
PMC5569465
DOI:
10.1186/s13104-017-2737-z
[Indexed for MEDLINE]
Free PMC Article

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