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Mol Cells. 2017 Aug;40(8):523-532. doi: 10.14348/molcells.2017.0153. Epub 2017 Aug 23.

Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models.

Author information

1
Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Korea.
2
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul 06351, Korea.
3
Department of Electronic Engineering, Hallym University, Kangwon 24252, Korea.

Abstract

Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique that indirectly assesses neuronal activity by measuring changes in oxygenated and deoxygenated hemoglobin in tissues using near-infrared light. fNIRS has been used not only to investigate cortical activity in healthy human subjects and animals but also to reveal abnormalities in brain function in patients suffering from neurological and psychiatric disorders and in animals that exhibit disease conditions. Because of its safety, quietness, resistance to motion artifacts, and portability, fNIRS has become a tool to complement conventional imaging techniques in measuring hemodynamic responses while a subject performs diverse cognitive and behavioral tasks in test settings that are more ecologically relevant and involve social interaction. In this review, we introduce the basic principles of fNIRS and discuss the application of this technique in human and animal studies.

KEYWORDS:

brain recording; fNIRS; functional near-infrared spectroscopy; functional neuroimaging; neurovascular coupling

PMID:
28835022
PMCID:
PMC5582298
DOI:
10.14348/molcells.2017.0153
[Indexed for MEDLINE]
Free PMC Article

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