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Adv Mater. 2017 Oct;29(39). doi: 10.1002/adma.201702888. Epub 2017 Aug 23.

Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design.

Author information

1
Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Av Eduardo Primo Yúfera 3, 46012, Valencia, Spain.
2
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
3
Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Carrer de Baldiri Reixac 15-21, 08028, Barcelona, Spain.

Abstract

The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded therapeutic properties and the complex interface of these materials with the biological environment. Herein, an unexpected charge-like attraction mechanism of self-assembly for star-shaped polyglutamates in nonsalty aqueous solutions is identified, which matches the ubiquitous "ordinary-extraordinary" phenomenon previously described by physicists. For the first time, a bottom-up methodology for the stabilization of these nanosized soft-assembled star-shaped polyglutamates is also described, enabling the translation of theoretical research into nanomaterials with applicability within the drug-delivery field. Covalent capture of these labile assemblies provides access to unprecedented architectures to be used as nanocarriers. The enhanced in vitro and in vivo properties of these novel nanoconstructs as drug-delivery systems highlight the potential of this approach for tumor-localized as well as lymphotropic delivery.

KEYWORDS:

charge-like; drug delivery; polymer therapeutics; polypeptides; self-assembly

PMID:
28834624
DOI:
10.1002/adma.201702888
[Indexed for MEDLINE]

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