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J Clin Lab Anal. 2018 Mar;32(3). doi: 10.1002/jcla.22308. Epub 2017 Aug 23.

Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.

Author information

1
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Abstract

OBJECTIVES:

Posttransplantation diabetes mellitus (PTDM) is a major complication after solid organ transplantation. This study is to investigate the association of nine genetic variant factors and PTDM in Chinese Han patients.

METHODS:

HLA-DP (rs3077, rs9277535), HLA-DQ (rs7453920), signal transducer and activator of transcription 4 (STAT4) (rs7574865), IL-28B (rs12979860, rs8099917, and rs12980275), and IL-18 (rs1946518 and rs187238) were investigated in 260 liver transplant recipients (PTDM vs non-PTDM) by high-resolution melting curve analysis. Serum interleukin (IL)-1β, IL-6, IL-8, IL-17, interferon-γ, inducible protein-10, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1b were analyzed by a Bio-Plex suspension array system (Bio-Plex Multiplex Immunoassays, Bio-Rad, Hercules, CA, USA).

RESULTS:

Signal transducer and activator of transcription 4 (rs7574865) T allele and IL-18 (rs1946518) A allele increase the risk for insulin resistance and PTDM.

CONCLUSIONS:

Recipients with STAT4 (rs7574865) T allele are associated with an increased concentration of IL-1β, interferon-γ, monocyte chemoattractant protein, and macrophage inflammatory protein-1b. The genetic variants of STAT4 (rs7574865) and IL-18 (rs1946518) may be new important markers for PTDM.

KEYWORDS:

PTDM ; HLA-DP; HLA-DQ; IL-18; IL-28B; STAT4

PMID:
28834572
DOI:
10.1002/jcla.22308
[Indexed for MEDLINE]

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