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J Hum Nutr Diet. 2018 Apr;31(2):168-177. doi: 10.1111/jhn.12503. Epub 2017 Aug 18.

Efficacy of vitamin D supplementation in combination with conventional antiviral therapy in patients with chronic hepatitis C infection: a meta-analysis of randomised controlled trials.

Author information

1
Department of Family Medicine, MyongJi Hospital, Goyang, Gyeonggi-do, Korea.
2
Department of Family Medicine, School of Medicine, Yonsei University, Seoul, Korea.
3
Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi-do, Korea.
4
Cancer Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Goyang, Korea.
5
Department of Family Medicine, Center for Cancer Prevention and Detection, Hospital, National Cancer Center, Goyang, Korea.
6
Department of Family Medicine, Gangnam Severance Hospital, Seoul, Korea.
7
Department of Family Medicine, Yongin Severance Hospital, Yongin, Gyeonggi-do, Korea.

Abstract

BACKGROUND:

Although a contributory role of vitamin D levels for the development of chronic hepatitis C has been suggested, the efficacy of vitamin D supplementation in combination with conventional antiviral therapy consisting of pegylated interferon-α (Peg-IFN-α) injection and oral ribavirin (RBV) remains unclear. We investigated its efficacy in the treatment of chronic hepatitis C via a meta-analysis of randomised controlled trials.

METHODS:

We searched PubMed, EMBASE, the Cochrane Library, ClinicalTrials.gov and the bibliographies of relevant articles to locate additional publications in September 2016. Three evaluators independently reviewed and selected eligible studies based on predetermined selection criteria.

RESULTS:

Of 522 articles meeting our initial criteria, a total of seven open-label, randomised controlled trials involving 548 participants, were included in the final analysis. Vitamin D supplementation in combination with Peg-IFN-α injection and oral RBV significantly increased the rate of viral response for hepatitis C at 24 weeks after treatment in a random-effects meta-analysis (relative risk = 1.30; 95% confidence interval = 1.04-1.62; I2 = 75.9%). Also, its significant efficacy was observed in patients with hepatitis C virus genotype 1, which is known to be refractory to antiviral therapy.

CONCLUSIONS:

In summary, we observed that additional use of vitamin D has a positive effect on sustained viral response rates of patients with chronic hepatitis C infection. However, we cannot establish the efficacy because of substantial heterogeneity, a small sample size and a low methodological quality.

KEYWORDS:

antiviral therapy; chronic hepatitis C; meta-analysis; randomised controlled trials; vitamin D supplementation

PMID:
28833855
DOI:
10.1111/jhn.12503
[Indexed for MEDLINE]

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