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Pharm Biol. 2017 Dec;55(1):2065-2073. doi: 10.1080/13880209.2017.1362010.

Effects of the hydroalcoholic extract of Rosa damascena on learning and memory in male rats consuming a high-fat diet.

Author information

1
a Neurophysiology Research Center , Hamadan University of Medical Sciences , Hamadan , Iran.
2
b Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy , Hamadan University of Medical Sciences , Hamadan , Iran.

Abstract

CONTEXT:

High-fat diet (HFD) can cause deficits in learning and memory through oxidative stress and increase Alzheimer disease risk. Rosa damascena Mill. (Rosaceae) extract possesses potent antioxidant properties.

OBJECTIVE:

This study investigated the effects of the hydroalcoholic extracts of petals of R. damascena on learning and memory in male rats consuming an HFD.

MATERIALS AND METHODS:

Forty male Wistar rats (200-250 g) were randomly assigned to four groups: control, R. damascena extract, HFD and HFD + extract. The extract (1 g/kg bw daily) was administered by oral gavage for 1 month. Animals were allowed free access to high-fat chow for 3 months. The Morris water maze and the passive avoidance learning tests were used to assess learning and memory.

RESULTS:

In the passive avoidance learning test, the step-through latencies in the retention test (STLr) of the extract (147.4 ± 23.3) and HFD (150.3 ± 25.2) groups were significantly lower than those of the control group (270.4 ± 10.5) (respectively, p < 0.001 and p < 0.01). STLr was significantly higher in the HFD + extract group (265.3 ± 10.6) than in the HFD group (150.3 ± 25.2) (p < 0.01). Time spent in the dark compartment (TDC) in the HFD + extract group (5.3 ± 2.6) was significantly lower than that in the HFD group (85.8 ± 19.1) (p < 0.05).

DISCUSSION AND CONCLUSION:

Our results indicate that, while HFD or R. damascena extract alone leads to memory deficits, R. damascena extract exerted a positive effect on HFD-induced memory deficits. We hypothesize that the observed effects of R. damascena extract are likely due to its strong antioxidant properties.

KEYWORDS:

Morris water maze; Oxidative stress; antioxidant; flavonoid; lipid profile; passive avoidance

PMID:
28832226
PMCID:
PMC6130717
DOI:
10.1080/13880209.2017.1362010
[Indexed for MEDLINE]
Free PMC Article

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