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J Headache Pain. 2017 Aug 23;18(1):90. doi: 10.1186/s10194-017-0800-8.

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine.

Author information

1
Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Nordre Ringvej 57, DK-2600, Copenhagen, Denmark.
2
Danish Headache Center, Department of Neurology, Glostrup Research Park, Rigshospitalet Glostrup, Copenhagen, Denmark.
3
Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Nordre Ringvej 57, DK-2600, Copenhagen, Denmark. ashina@dadlnet.dk.

Abstract

BACKGROUND:

To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.

DISCUSSION:

KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.

CONCLUSION:

We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

KEYWORDS:

Cromakalim; Headache; KATP channel; KATP channels; Levcromakalim; Migraine

PMID:
28831746
PMCID:
PMC5567577
DOI:
10.1186/s10194-017-0800-8
[Indexed for MEDLINE]
Free PMC Article

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