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Gastroenterol Res Pract. 2017;2017:7089702. doi: 10.1155/2017/7089702. Epub 2017 Jul 31.

Gamma-Glutamyl Transpeptidase-to-Platelet Ratio Predicts Significant Liver Fibrosis of Chronic Hepatitis B Patients in China.

Ren T1, Wang H1, Wu R1,2, Niu J1,2,3.

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Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Jilin Province Key Laboratory of Infectious Disease, Laboratory of Molecular Virology, Changchun 130021, China.
Key Laboratory of Zoonosis Research, Ministry Education, Changchun, Jilin 130021, China.



We want to investigate whether a novel noninvasive marker is suitable for Chinese CHB patients.


A total of 160 treatment-naïve CHB patients who underwent liver biopsy were enrolled in our study, and we assessed the diagnostic accuracies of GPR, aspartate transaminase-to-platelet ratio index (APRI), and the fibrosis index based on 4 factors (FIB-4) in them.


Of these 160 CHB patients, the numbers of F0, F1, F2, F3, and F4 are 34 (21.3%), 62 (38.8%), 18 (11.3%), 24 (15%), and 22 (13.8%), respectively. The area under the receiver operating characteristic curves (AUROC) of GPR for fibrosis (0.77 versus 0.70, P = 0.03), significant fibrosis (0.70 versus 0.63, P = 0.02), and extensive fibrosis (0.71 versus 0.64, P = 0.02) were significantly higher than those of APRI. The AUROCs of GPR and Fib-4 for fibrosis (0.77 versus 0.75, P = 0.14), significant fibrosis (0.70 versus 0.70, P = 0.22), extensive fibrosis (0.71 versus 0.68, P = 0.13), and cirrhosis (0.64 versus 0.67, P = 0.24) were comparable.


The GPR can be a routine laboratory marker to stage liver fibrosis in patients with CHB in China.

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