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Brain Behav. 2017 Jun 21;7(8):e00753. doi: 10.1002/brb3.753. eCollection 2017 Aug.

Diffusion tensor imaging of the structural integrity of white matter correlates with impulsivity in adolescents with internet gaming disorder.

Author information

1
Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital Tianjin China.
2
Department of Psychology Linyi Fourth People's Hospital Linyi Shandong China.
3
Department of Radiology Linyi People's Hospital Linyi Shandong China.

Abstract

INTRODUCTION:

Internet gaming disorder (IGD) is usually defined as the inability of an individual to control internet gaming resulting in serious negative consequences, and trait impulsivity has been viewed as a hallmark feature of IGD. Recent studies have suggested that the structural integrity of the white matter (WM) plays an important role in the neuromediation of an individual's impulsivity. However, no study has examined the association between WM integrity and impulsivity in IGD adolescents.

METHODS:

In this study, 33 adolescents with IGD and 32 healthy controls (HCs) were recruited, and the intergroup differences in the relationships between impulsivity and fractional anisotropy (FA) values across the whole brain WM were investigated using voxel-wise correlation analyses.

RESULTS:

Our results revealed significant intergroup differences in the correlations between impulsivity and the FA values of the right corticospinal tract (CST) and the right occipital WM. Region of interest-based tests revealed that the FA values of these clusters were positive or insignificantly correlated with impulsivity in the IGD adolescents contrasted to the significantly negative correlation in the HCs.

CONCLUSIONS:

This altered correlations in the IGD adolescents might reflect potential WM microstructural changes which may be associated with the greater impulsivity of IGD adolescents and provide possible therapeutic targets for interventions in this population.

KEYWORDS:

diffusion tensor imaging; impulsivity; internet gaming disorder; white matter

PMID:
28828214
PMCID:
PMC5561314
DOI:
10.1002/brb3.753
[Indexed for MEDLINE]
Free PMC Article

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