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J Hum Kinet. 2017 Aug 1;58:65-72. doi: 10.1515/hukin-2017-0071. eCollection 2017 Sep.

Creatine Kinase and Lactate Dehydrogenase Responses after Different Resistance and Aerobic Exercise Protocols.

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Methodist University Center, Program of Academic Master of Bioscience and Rehabilitation, Rio Grande do Sul, Brazil.
Federal University of Rio de Janeiro (UFRJ), Department of Physical Education, Graduate Program, Rio de Janeiro, RJ, Brazil.
Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Paraíba, Brazil.
Federal University of Rio de Janeiro (UFRJ), Medical Clinic Postgraduate Program, Rio de Janeiro, Brazil.
Research Center in Sports Sciences, Health Sciences and Human Development, Vila Real, Portugal.


The aim of this study was to investigate the responses of creatine kinase (CK) and lactate dehydrogenase (LDH) after performing different resistance and aerobic exercise protocols. Twelve recreationally trained men (age, 23.2 ± 5.6 years; body mass, 84.3 ± 9.3 kg; body height, 178.9 ± 4.5 cm; and BMI, 26.3 ± 2.3 kg·m2) volunteered to participate in this study. All subjects were randomly assigned to four experimental protocols (crossover): (a) aerobic training at 60% of VO2max, (b) aerobic training at 80% of VO2max, (c) a resistance exercise (RE) session with a bi-set protocol, and (d) an RE session with a multiple sets protocol. Blood samples were collected before, immediately after and 24 hours following the experimental protocols. After 24 hours, there was a significant increase in CK for the 80% of VO2max protocol vs. the bi-set RE session (p = 0.016). Immediately after the protocols, we observed a significant increase in LDH among certain groups compared to others, as follows: multiple sets RE session vs. 60% of VO2max, bi-set RE session vs. 60% of VO2max, multiple sets RE session vs. 80% of VO2max, and bi-set RE session vs. 80% of VO2max (p = 0.008, p = 0.013; p = 0.002, p = 0.004, respectively). In conclusion, aerobic exercise performed at 80% of VO2max appears to elevate plasma CK levels more than bi-set RE sessions. However, the bi-set and multiple sets RE sessions appeared to trigger greater levels of blood LDH compared to aerobic protocols performed at 60% and 80% of VO2max.


endurance training; muscle damage; resistance training

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