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Physica A. 2017 Apr 15;472:86-93. doi: 10.1016/j.physa.2016.12.086. Epub 2017 Jan 4.

A physical model for dementia.

Author information

1
CInC-(IICBA), Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico.
2
CIICAP-(IICBA), Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico.
3
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
4
Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
5
Department of Psychology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
6
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology (CTB), Campus de Montegancedo s/n, Pozuelo de Alarcón, 28223, Madrid, Spain.
7
Alzheimer Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, 08029 Barcelona, Spain.

Abstract

Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. A probabilistic model for the development of dementia is obtained and fitted to some experimental data obtained from the Alzheimer's Disease Neuroimaging Initiative. It is explained how dementia appears as a consequence of aging and why it is irreversible.

KEYWORDS:

Catastrophe theory; Cusp; Dementia; Stochastic process

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