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Allergol Int. 2017 Oct;66(4):515-522. doi: 10.1016/j.alit.2017.07.010. Epub 2017 Aug 18.

Development of the gut microbiota in infancy and its impact on health in later life.

Author information

1
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
2
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan. Electronic address: nakayama@agr.kyushu-u.ac.jp.

Abstract

Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.

KEYWORDS:

Allergy; Bifidobacterium; Gut microbiota; Hygiene hypothesis; Infants

PMID:
28826938
DOI:
10.1016/j.alit.2017.07.010
[Indexed for MEDLINE]
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