Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report

World Neurosurg. 2017 Nov:107:1046.e1-1046.e7. doi: 10.1016/j.wneu.2017.07.151. Epub 2017 Aug 4.

Abstract

Background: Intramedullary ependymal cysts of the spinal cord are rare, benign, fluid-filled cysts usually situated along the ventral surface of the spinal cord. Only 32 cases have been reported since they were first described. Thus, owing to the rarity at which these cysts are encountered, their management and pathogenesis remain controversial. Whereas some investigators have advocated for cystosubarachnoid shunt placement for symptomatic ependymal cysts, others have argued for complete cyst resection or simple fenestration. Here we report the case of a 56-year-old female with a T11-T12 ependymal cyst that was successfully managed with cyst fenestration. We further investigated a potential pathological mechanism of cyst formation by performing immunohistochemistry to detect aquaporin expression in the cyst lining.

Case description: A 56-year-old female was found to harbor an enlarging cystic lesion of the conus that was discovered on workup of progressive paraparesis and urinary incontinence. She had lower extremity weakness and progressive myelopathy. Thoracic laminectomy with cyst fenestration arrested her neurologic deterioration. Pathological analysis revealed an intramedullary ependymal cyst. Immunohistochemistry was subsequently performed for expression of aquaporin-1 and aquaporin-4. There was dense staining of the underlying neuropil with concurrent membranous staining pattern of the cyst lining.

Conclusions: Intramedullary ependymal cysts are rare, cystic lesions of the spinal cord. Early cyst fenestration decompresses the cyst and prevents neurologic deterioration. Here we report for the first time that aquaporins are expressed in the cyst wall, which is consistent with a passive, osmotic pathogenic mechanism of cyst formation.

Keywords: Aquaporin; Ependymal cyst; Epithelial cyst; Syringomyelia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aquaporin 1 / biosynthesis*
  • Aquaporin 1 / genetics
  • Aquaporin 4 / biosynthesis*
  • Aquaporin 4 / genetics
  • Central Nervous System Cysts / diagnostic imaging
  • Central Nervous System Cysts / metabolism*
  • Central Nervous System Cysts / surgery
  • Ependyma / diagnostic imaging
  • Ependyma / metabolism*
  • Ependyma / surgery
  • Female
  • Gene Expression
  • Humans
  • Middle Aged
  • Spinal Cord / diagnostic imaging
  • Spinal Cord / metabolism*
  • Spinal Cord / surgery

Substances

  • AQP1 protein, human
  • AQP4 protein, human
  • Aquaporin 4
  • Aquaporin 1