Format

Send to

Choose Destination
Elife. 2017 Aug 17;6. pii: e27167. doi: 10.7554/eLife.27167.

Genetic variation in adaptability and pleiotropy in budding yeast.

Author information

1
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
2
Department of Physics, Harvard University, Cambridge, United States.
3
FAS Center for Systems Biology, Harvard University, Cambridge, United States.
4
Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California, San Diego, San Diego, United States.
5
Department of Human Genetics, University of California, Los Angeles, Los Angeles, United States.
#
Contributed equally

Abstract

Evolution can favor organisms that are more adaptable, provided that genetic variation in adaptability exists. Here, we quantify this variation among 230 offspring of a cross between diverged yeast strains. We measure the adaptability of each offspring genotype, defined as its average rate of adaptation in a specific environmental condition, and analyze the heritability, predictability, and genetic basis of this trait. We find that initial genotype strongly affects adaptability and can alter the genetic basis of future evolution. Initial genotype also affects the pleiotropic consequences of adaptation for fitness in a different environment. This genetic variation in adaptability and pleiotropy is largely determined by initial fitness, according to a rule of declining adaptability with increasing initial fitness, but several individual QTLs also have a significant idiosyncratic role. Our results demonstrate that both adaptability and pleiotropy are complex traits, with extensive heritable differences arising from naturally occurring variation.

KEYWORDS:

S. cerevisiae; adaptability; evolutionary biology; experimental evolution; genomics; pleiotropy

PMID:
28826486
PMCID:
PMC5580887
DOI:
10.7554/eLife.27167
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for eLife Sciences Publications, Ltd Icon for PubMed Central
Loading ...
Support Center