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Nat Prod Res. 2018 Sep;32(18):2225-2228. doi: 10.1080/14786419.2017.1366485. Epub 2017 Aug 22.

Antimicrobial and anti-biofilm activity of tannic acid against Staphylococcus aureus.

Author information

1
a School of Laboratory Medicine and Life Science , Wenzhou Medical University , Wenzhou , China.
2
b Department of Clinical Laboratory , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
3
c The First Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.

Abstract

Tannic acid, a rich of natural and process-derived phenolic compound, has been shown to be an effective antagonist against viruses and bacteria. In this study, we determined the antimicrobial activity and mechanisms of tannic acid against Staphylococcus aureus with emphasis on inhibiting effect on biofilm formation. Based on the results of time-kill assay, binding ability assay, lysozyme susceptibility assay and the transmission electron microscope, we tentatively speculated that peptidoglycan might be the target of the process that tannic acid destroy the integrity of cell wall, moreover, tannic acid could reduce the biofilm formation at sub-MIC concentrations. These results manifested that natural product tannic acid could serve as a potentially effective candidate for development of novel strategies to treat methicillin-resistant S. aureus infections.

KEYWORDS:

Biofilm; MRSA; Staphylococcus aureus; tannic acid

PMID:
28826250
DOI:
10.1080/14786419.2017.1366485
[Indexed for MEDLINE]

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