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J Alzheimers Dis. 2017;60(1):253-262. doi: 10.3233/JAD-170470.

Incident Cerebral Microbleeds Detected by Susceptibility Weight-Imaging Help to Identify Patients with Mild Cognitive Impairment Progressing to Alzheimer's Disease.

Author information

1
Service de Neuro-Radiologie, Centre Hospitalier Universitaire Toulouse - Purpan, Hôpital Pierre Paul Riquet, Toulouse, France.
2
BioClinica, Lyon, France; Newtown, PA, USA.
3
Institut de Recherches Internationales Servier, Suresnes, France.
4
Gerontopôle, Alzheimer's Research and Clinical Center, CHU Toulouse, CMRR Midi-Pyrénées, France.

Abstract

BACKGROUND:

The relationship between cerebral microbleeds (CMB) and Alzheimer's disease (AD) has not yet been clearly determined, particularly with susceptibility weight-imaging (SWI).

OBJECTIVE:

To evaluate the SWI sequence using 3T MRI for the detection of CMB, and its ability to differentiate elderly control subjects (CS), stable mild cognitive impairment patients (MCI-s), MCI patients progressing to AD (MCI-p), and AD patients.

METHODS:

It was a prospective, monocentric, observational study that took place in Toulouse, France. Participants were 65 years and older, enrolled in three groups: CS, MCI, and AD. Based on the longitudinal analysis of cognitive decline, MCI subjects were retrospectively classified as MCI-s or MCI-p. Each patient had a 4-year follow-up with MRI at baseline (MRI#1) and during the fourth year (MRI#3). CMB were counted on native SWI images juxtaposed to minIP reformatted images.

RESULTS:

150 patients were enrolled: 48 CS, 25 MCI-s, 18 MCI-p, 59 AD. At MRI#1 and at MRI#3, there was no significant difference in the prevalence of CMB between groups (p = 0.75 and p = 0.87). In the MCI-p + AD group, significantly more subjects had≥4 incident CMB compared to the CS + MCI-s group (p = 0.016). In the MCI-p + AD group, the prevalence of patients with >4 CMB was significantly higher at MRI#3 than at MRI#1 (p = 0.008).

CONCLUSION:

Using SWI, AD and MCI-p patients had developed significantly more new CMB than CS and MCI-s patients during the follow-up. Incident CMB might be suggested as a potential imaging marker of AD progression.

KEYWORDS:

Alzheimer’s disease; disease progression; imaging biomarker; incident cerebral microbleeds; longitudinal MRI; mild cognitive impairment; susceptibility weight imaging

PMID:
28826188
DOI:
10.3233/JAD-170470
[Indexed for MEDLINE]

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