Format

Send to

Choose Destination
J Nutr Biochem. 2017 Oct;48:128-137. doi: 10.1016/j.jnutbio.2017.07.003. Epub 2017 Jul 10.

Effects of delta-tocotrienol on obesity-related adipocyte hypertrophy, inflammation and hepatic steatosis in high-fat-fed mice.

Author information

1
Department of Nutritional Sciences, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409; Obesity Research Cluster, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409.
2
Department of Nutritional Sciences, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409.
3
Obesity Research Cluster, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409; Department of Pathology, Texas Tech University Health Science Center, 3601 4th Street, Lubbock, TX 79430.
4
Department of Pathology, Texas Tech University Health Science Center, 3601 4th Street, Lubbock, TX 79430.
5
Obesity Research Cluster, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409; Department of Cell Biology and Biochemistry, Texas Tech University Health Science Center, 3601 4th Street, Lubbock, TX 79430.
6
Department of Kinesiology, Health and Nutrition, University of Texas at San Antonio, 1 Utsa Circle, San Antonio, TX 78249.
7
Department of Nutritional Sciences, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409; Obesity Research Cluster, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409; Department of Physiology, Faculty of Medicine, University of Peradeniya, Sri Lanka.
8
Department of Nutritional Sciences, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409; Obesity Research Cluster, Texas Tech University, 1301 Akron Avenue, Lubbock, TX 79409. Electronic address: naima.moustaid-moussa@ttu.edu.

Abstract

Inflammation is a major underlying cause for obesity-associated metabolic diseases. Hence, anti-inflammatory dietary components may improve obesity-related disorders. We hypothesized that delta-tocotrienol (δT3), a member of the vitamin E family, reduces adiposity, insulin resistance and hepatic triglycerides through its anti-inflammatory properties. To test this hypothesis, C57BL/6J male mice were fed a high-fat diet (HF) with or without supplementation of δT3 (HF+δT3) at 400 mg/kg and 1600 mg/kg for 14 weeks, and they were compared to mice fed a low-fat diet (LF) or HF supplemented with metformin as an antidiabetic control. Glucose tolerance tests were administered 2 weeks prior to the end of treatments. Histology, quantitative polymerase chain reaction and protein analyses were performed to assess inflammation and fatty acid metabolism in adipose and liver tissues. Significant improvements in glucose tolerance, and reduced hepatic steatosis and serum triglycerides were observed in δT3-supplemented groups compared to the HF group. Body and fat pad weights were not significantly reduced in HF+δT3 groups; however, we observed smaller fat cell size and reduced macrophage infiltration in their adipose tissues compared to other groups. These changes were at least in part mechanistically explained by a reduction of mRNA and protein expression of proinflammatory adipokines and increased expression of anti-inflammatory adipokines in HF+δT3 mice. Moreover, δT3 dose-dependently increased markers of fatty acid oxidation and reduced markers of fatty acid synthesis in adipose tissue and liver. In conclusion, our studies suggest that δT3 may promote metabolically healthy obesity by reducing fat cell hypertrophy and decreasing inflammation in both liver and adipose tissue.

KEYWORDS:

Adipose tissue; Anti-inflammatory; Liver; Obesity; delta-Tocotrienol

PMID:
28825992
DOI:
10.1016/j.jnutbio.2017.07.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center