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J Am Chem Soc. 2017 Sep 6;139(35):12149-12152. doi: 10.1021/jacs.7b07460. Epub 2017 Aug 24.

Directed Biofabrication of Nanoparticles through Regulating Extracellular Electron Transfer.

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CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Beijing Synchrotron Radiation Laboratory, Institute of High Energy Physics, Chinese Academy of Science , Beijing 100049, China.
National Synchrotron Radiation Laboratory, University of Science and Technology of China , Hefei 230026, China.


Biofabrication of nanomaterials is currently constrained by a low production efficiency and poor controllability on product quality compared to chemical synthetic routes. In this work, we show an attractive new biosynthesis system to break these limitations. A directed production of selenium-containing nanoparticles in Shewanella oneidensis MR-1 cells, with fine-tuned composition and subcellular synthetic location, was achieved by modifying the extracellular electron transfer chain. By taking advantage of its untapped intracellular detoxification and synthetic power, we obtained high-purity, uniform-sized cadmium selenide nanoparticles in the cytoplasm, with the production rates and fluorescent intensities far exceeding the state-of-the-art biosystems. These findings may fundamentally change our perception of nanomaterial biosynthesis process and lead to the development of fine-controllable nanoparticles biosynthesis technologies.


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