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Int J Mol Sci. 2017 Aug 21;18(8). pii: E1809. doi: 10.3390/ijms18081809.

Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells.

Author information

1
Department of Animal Science, Chonnam National University, Gwangju 61186, Korea. trongxuan.vp@gmail.com.
2
Department of Animal Science, Chonnam National University, Gwangju 61186, Korea. seohee55@jnu.ac.kr.
3
Department of Animal Science, Chonnam National University, Gwangju 61186, Korea. ugun2@naver.com.
4
Department of Food Science and Technology, BK21 Plus Program, Chonnam National University, Gwangju 61186, Korea. wjdgkddus@naver.com.
5
Department of Food Science and Technology, BK21 Plus Program, Chonnam National University, Gwangju 61186, Korea. nutrmoon@chonnam.ac.kr.
6
Department of Animal Science, Chonnam National University, Gwangju 61186, Korea. tjeon@jnu.ac.kr.

Abstract

Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component, protocatechuic acid (PCA), on melanogenesis in mouse melanoma cells. We found that PE and PCA significantly suppressed melanin content and cellular tyrosinase activity through a decrease in the expression of melanogenic enzymes and microphthalmia-associated transcription factor (Mitf) in α-melanocyte stimulating hormone-stimulated mouse melanoma cells. Moreover, PCA decreased cyclic adenosine monophosphate (cAMP) levels and cAMP-responsive element-binding protein phosphorylation, which downregulated Mitf promoter activation and subsequently mediated the inhibition of melanogenesis. These results suggested that pear may be an effective skin lightening agent that targets either a tyrosinase activity or a melanogenic pathway.

KEYWORDS:

hyperpigmentation; melanogenesis; melanoma; pear; protocatechuic acid

PMID:
28825660
PMCID:
PMC5578196
DOI:
10.3390/ijms18081809
[Indexed for MEDLINE]
Free PMC Article

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