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Int J Mol Sci. 2017 Aug 19;18(8). pii: E1804. doi: 10.3390/ijms18081804.

FANCD2 and DNA Damage.

Nepal M1,2, Che R3,4, Ma C5, Zhang J6, Fei P7,8.

Author information

1
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. Mnepal@cc.hawaii.edu.
2
Graduate Program of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96813, USA. Mnepal@cc.hawaii.edu.
3
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. rche@hawaii.edu.
4
Graduate Program of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96813, USA. rche@hawaii.edu.
5
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. cma@cc.hawaii.edu.
6
Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, Rochester, MN 55905, USA. zhang.jun@mayo.edu.
7
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. pfei@cc.hawaii.edu.
8
Graduate Program of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96813, USA. pfei@cc.hawaii.edu.

Abstract

Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.

KEYWORDS:

DNA damage repair; FANCD2; Fanconi anemia; cancer and aging; checkpoint

PMID:
28825622
PMCID:
PMC5578191
DOI:
10.3390/ijms18081804
[Indexed for MEDLINE]
Free PMC Article

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