Format

Send to

Choose Destination
Lupus. 2018 Feb;27(2):327-332. doi: 10.1177/0961203317725585. Epub 2017 Aug 21.

Medication adherence, depression and disease activity among patients with systemic lupus erythematosus.

Author information

1
1 Pharmacy Services, 37850 King Saud University Medical City, Riyadh, Saudi Arabia.
2
2 College of Pharmacy, 37850 King Saud University , Riyadh, Saudi Arabia.
3
3 Department of Clinical Pharmacy, College of Pharmacy, 37850 King Saud University , Riyadh, Saudi Arabia.
4
4 Division of Nephrology, Department of Medicine, College of Medicine, 37850 King Saud University , Riyadh, Saudi Arabia.
5
5 Division of Rheumatology, Department of Medicine, College of Medicine, 37850 King Saud University , Riyadh, Saudi Arabia.

Abstract

Introduction Medication non-adherence is an important cause of treatment failure among patients with systemic lupus erythematosus (SLE). Depression is a common neuropsychiatric disorder associated with SLE. The aims of this study are to assess the prevalence of both medication non-adherence and depressed mood among Saudi patients with SLE by using validated tools and to explore the impact of both depressive symptoms and disease activity on medication non-adherence. Methods A cross-sectional study was conducted in outpatients with SLE. Medication non-adherence was assessed by using the Morisky Medication Adherence Scale, and the severity of depressed mood was evaluated with the Beck's Depression Inventory. Disease activity was measured using the SLE Disease Activity Index (SLEDAI). Multiple logistic regression models were used to identify the multivariate predictors of medication non-adherence. Results Out of 140 patients, 134 (95.7%) were females with a mean (±SD) age of 35.6 (±11.3) years and a disease duration of 8.8 (±6.7) years. Medication non-adherence and depressed mood were detected in 62.1% and 35% of the patients, respectively. A moderate or severe depressed mood was significantly associated with medication non-adherence ( p = 0.04). There was a significant correlation between disease activity and the severity of depressed mood ( r = 0.31, p = 0.003). Disease activity did not correlate with medication non-adherence. Logistic regression demonstrated that moderate-to-severe depressed mood increased the probability of medication non-adherence (OR 2.62; 1.02-6.71). Conclusion Medication non-adherence and depressive symptoms are highly prevalent among Saudi SLE patients. Routine screening could facilitate the early detection and management of depression and medication adherence.

KEYWORDS:

Systemic lupus erythematosus; adherence; depression

PMID:
28825347
DOI:
10.1177/0961203317725585
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center