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Theranostics. 2017 Jul 30;7(11):2965-2967. doi: 10.7150/thno.21603. eCollection 2017.

New Kid on the Block.

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Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert-Ludwigs-University Freiburg, and German Cancer Consortium (DKTK), Partner site Freiburg, Freiburg, Germany.


Cysteine cathepsins are a group of proteases involved in many physiological and pathological processes. Yet, the selective detection and inhibition of individual cathepsins is still challenging. This editorial is discussing the context of a recent work introducing a designed ankyrin repeat protein (DARPin) as novel approach for selective targeting of the protease cathepsin B.


Cathepsin B; DARPin; protease imaging; protease inhibition

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