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Front Psychol. 2017 Jul 31;8:1292. doi: 10.3389/fpsyg.2017.01292. eCollection 2017.

Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.

Author information

1
Neurophysiopathology of Pain, Basic Medical Science, Neuroscience and Sensory System Department-SMBNOS-Bari Aldo Moro UniversityBari, Italy.
2
Department of Biological and Environmental Sciences and Technologies, University of SalentoLecce, Italy.

Abstract

Objective: To compare interference between walking and a simple P3 auditory odd-ball paradigm in patients with Huntington's disease (HD) and age- and sex-matched controls. Methods: Twenty-four early-to-middle-stage HD patients and 14 age- and sex-matched healthy volunteers were examined. EEG-EMG recordings were obtained from 21 scalp electrodes and eight bipolar derivations from the legs. Principal component analysis was used to obtain artifact-free recordings. The stimulation paradigm consisted of 50 rare and 150 frequent stimuli and was performed in two conditions: standing and walking along a 10 by 5 m path. P3 wave amplitude and latency and EEG and EMG spectral values were compared by group and experimental condition and correlated with clinical features of HD. Results: P3 amplitude increased during walking in both HD patients and controls. This effect was inversely correlated with motor impairment in HD patients, who showed a beta-band power increase over the parieto-occipital regions in the walking condition during the P3 task. Walking speed and counting of rare stimuli were not compromised by concurrence of motor and cognitive demands. Conclusion: Our results showed that walking increased P3 amplitude in an auditory task, in both HD patients and controls. Concurrent cognitive and motor stimulation could be used for rehabilitative purposes as a means of enhancing activation of cortical compensatory reserves, counteracting potential negative interference and promoting the integration of neuronal circuits serving different functions.

KEYWORDS:

Huntington's disease; P3; acoustic paradigm; dual task; walking

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