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Intern Med. 2017 Sep 15;56(18):2475-2479. doi: 10.2169/internalmedicine.8571-16. Epub 2017 Aug 21.

Effectiveness of Plasmapheresis in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis with Advanced Kidney Dysfunction.

Author information

1
Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan.
2
Department of Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Japan.

Abstract

Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He required hemodialysis. All glomeruli in the kidney biopsy specimen had cellular crescents without fibrotic changes, suggesting reversible damage. He was treated with plasmapheresis until the anti-glomerular basement membrane antibodies disappeared. His kidney function recovered, and dialysis was able to be discontinued. Frequent plasmapheresis in patients with dialysis-dependent anti-GBM GN may improve the kidney prognosis.

KEYWORDS:

anti-glomerular basement membrane antibody glomerulonephritis; dialysis; glomerular crescents; plasmapheresis

PMID:
28824070
PMCID:
PMC5643177
DOI:
10.2169/internalmedicine.8571-16
[Indexed for MEDLINE]
Free PMC Article

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