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Trends Microbiol. 2018 Jan;26(1):33-42. doi: 10.1016/j.tim.2017.07.006. Epub 2017 Aug 16.

Mechanisms of Hepatitis B Virus Persistence.

Author information

1
Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
2
Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. Electronic address: jamesou@hsc.usc.edu.

Abstract

Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. It can also take advantage of the developing immune system and the not-yet-stabilized gut microbiota of young children to facilitate its persistence, and use maternal viral e antigen to educate immunity of the offspring to support its persistence after vertical transmission. The knowledge gained from these recent studies paves the way for the development of new therapies for the treatment of chronic HBV infection, which has so far been very challenging.

KEYWORDS:

HBV e antigen; age and maternal effects; chronic hepatitis B; interferon immune responses; vertical transmission

PMID:
28823759
PMCID:
PMC5741523
DOI:
10.1016/j.tim.2017.07.006
[Indexed for MEDLINE]
Free PMC Article

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