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Trends Immunol. 2017 Oct;38(10):758-767. doi: 10.1016/j.it.2017.07.004. Epub 2017 Aug 16.

NOD1 and NOD2: Beyond Peptidoglycan Sensing.

Author information

1
University of Colorado, School of Medicine, Aurora, CO, USA.
2
Department of Medical Microbiology and Immunology, University of California at Davis, School of Medicine, Davis, CA USA. Electronic address: rmtsolis@ucdavis.edu.

Abstract

NOD1 and NOD2 are pattern recognition receptors of the innate immune system with well-established roles in sensing fragments of bacterial peptidoglycan. In addition to their role as microbial sensors, recent evidence indicates that nucleotide-binding oligomerization domains (NODs) can also recognize a broader array of danger signals. Indeed, recent work has expanded the roles of NOD1 and NOD2 to encompass not only sensing of infections with viruses and parasites but also perceiving perturbations of cellular processes such as regulation of the actin cytoskeleton and maintenance of endoplasmic reticulum homeostasis. This review will comment on recent progress and point out emerging questions in these areas.

PMID:
28823510
PMCID:
PMC5624830
DOI:
10.1016/j.it.2017.07.004
[Indexed for MEDLINE]
Free PMC Article

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