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J Biomed Opt. 2017 Aug;22(8):1-10. doi: 10.1117/1.JBO.22.8.086005.

Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study.

Author information

1
British Columbia Cancer Research Centre, Department of Integrative Oncology, Vancouver, British Colu, Canada.
2
The University of British Columbia, Faculty and Dentistry, Vancouver, British Columbia, Canada.

Abstract

Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo.

KEYWORDS:

biomedical optics; endomicroscopy; fluorescence; in vivo pathology; light scattering

PMID:
28823113
DOI:
10.1117/1.JBO.22.8.086005
[Indexed for MEDLINE]

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