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J Biotechnol. 2017 Nov 10;261:131-136. doi: 10.1016/j.jbiotec.2017.08.010. Epub 2017 Aug 16.

Lipidomics informatics for life-science.

Author information

1
Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.
2
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
3
Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
4
Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany. Electronic address: robert.ahrends@isas.de.

Abstract

Lipidomics encompasses analytical approaches that aim to identify and quantify the complete set of lipids, defined as lipidome in a given cell, tissue or organism as well as their interactions with other molecules. The majority of lipidomics workflows is based on mass spectrometry and has been proven as a powerful tool in system biology in concert with other Omics disciplines. Unfortunately, bioinformatics infrastructures for this relatively young discipline are limited only to some specialists. Search engines, quantification algorithms, visualization tools and databases developed by the 'Lipidomics Informatics for Life-Science' (LIFS) partners will be restructured and standardized to provide broad access to these specialized bioinformatics pipelines. There are many medical challenges related to lipid metabolic alterations that will be fostered by capacity building suggested by LIFS. LIFS as member of the 'German Network for Bioinformatics' (de.NBI) node for 'Bioinformatics for Proteomics' (BioInfra.Prot) and will provide access to the described software as well as to tutorials and consulting services via a unified web-portal.

KEYWORDS:

Bioinformatics; LIFS; LipidCreator; LipidXplorer; Lipidomics; Lux-Score; Skyline

PMID:
28822794
DOI:
10.1016/j.jbiotec.2017.08.010
[Indexed for MEDLINE]

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