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Can J Diabetes. 2018 Jun;42(3):325-334. doi: 10.1016/j.jcjd.2017.06.008. Epub 2017 Aug 16.

Managing the Course of Kidney Disease in Adults With Type 2 Diabetes: From the Old to the New.

Author information

1
LMC Diabetes & Endocrinology, Thornhill, Ontario, Canada. Electronic address: ronaldgoldenberg@gmail.com.
2
Vaughan Heart Institute, Humber River Hospital, Toronto, Ontario, Canada.
3
Division of Nephrology, University Health Network, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
4
Division of Endocrinology & Metabolism, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
5
Division of Nephrology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
6
University of Alberta, Edmonton, Alberta, Canada.
7
Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Abstract

Diabetic kidney disease (DKD) is a group of chronic kidney diseases that is associated with significant cardiovascular as well as all-cause morbidity and mortality. Although DKD is often progressive in nature, its evolution can be modified by intensive management of glycemia and blood pressure and inhibition of the renin-angiotensin-aldosterone system. This review provides an overview of how multifactorial interventions can provide renal protection and includes a discussion of the nonglycemic effects of incretin-based diabetes therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors) and sodium-glucose cotransporter-2 inhibitors within the kidney in patients with type 2 diabetes.

KEYWORDS:

DPP-4 inhibitors; GLP-1R agonists; SGLT2 inhibitors; agonistes des récepteurs GLP-1; blood pressure; diabetic kidney disease; glycemia; glycémie; inhibiteurs de la DPP-4; inhibiteurs du SGLT2; néphropathie diabétique; pression artérielle

PMID:
28822777
DOI:
10.1016/j.jcjd.2017.06.008
[Indexed for MEDLINE]

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