Format

Send to

Choose Destination
J Biol Chem. 2017 Aug 18;292(33):13902-13903. doi: 10.1074/jbc.H117.783860.

Flipping a citrate switch on liver cancer cells.

Author information

1
From the Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802 jmp21@psu.edu.

Abstract

Energy homeostasis and oncogenic signaling are critical determinants of the growth of human liver cancer cells, providing a strong rationale to elucidate the regulatory mechanisms for these systems. A new study reports that loss of solute carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell growth by altering both energy production and mammalian target of rapamycin signaling in human liver cancer cell lines and in both an in vitro and in vivo model of liver tumors, suggesting a new target for liver cancer chemoprevention and/or chemotherapy.

PMID:
28821606
PMCID:
PMC5566541
DOI:
10.1074/jbc.H117.783860
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center