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Biochem Biophys Res Commun. 2017 Oct 14;492(2):206-211. doi: 10.1016/j.bbrc.2017.08.050. Epub 2017 Aug 15.

Effect of micro strain stress on proliferation of endothelial progenitor cells in vitro by the MAPK-ERK1/2 signaling pathway.

Author information

1
Department of Orthopedics, Tianjin Medical University General Hospital, 154, Anshan Street, Heping District, Tianjin 300052, China; Institute of Orthopedics, Tianjin Hospital, Tianjin, China.
2
Institute of Orthopedics, Tianjin Hospital, Tianjin, China.
3
Institute of Orthopedics, Tianjin Hospital, Tianjin, China. Electronic address: mjx969@163.com.
4
Department of Orthopedics, Tianjin Medical University General Hospital, 154, Anshan Street, Heping District, Tianjin 300052, China; Institute of Orthopedics, Tianjin Hospital, Tianjin, China. Electronic address: agzhb@sina.com.

Abstract

BACKGROUND:

The aim of this study was to analyze the effect of micro strain stress on the proliferation of endothelial progenitor cells in vitro by the MAPK-ERK1/2 signaling pathway.

MATERIAL AND METHODS:

In this study, we report the effect of micro strain stress on proliferation of endothelial progenitor cells (EPCs) in vitro by loading different types of micro strain stress on EPCs. We also explore the possible mechanisms of this phenomenon.

RESULTS:

The results of flow cytometry show that appropriate micro strain stress can promote EPC proliferation. This phenomenon coincides with the upregulation of multiple genes or proteins affecting cell proliferation, including Cyclin D1, Proliferating Cell Nuclear Antigen (PCNA) and phospho-ERK1/2.

CONCLUSION:

The results collectively suggest that proper mechanical stimulation can promote the proliferation of EPCs and promote angiogenesis.

KEYWORDS:

Endothelial progenitor cells; MAPK-ERK1/2; Micro strain stress; Proliferation

PMID:
28821432
DOI:
10.1016/j.bbrc.2017.08.050
[Indexed for MEDLINE]

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