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Transcription. 2018;9(2):95-101. doi: 10.1080/21541264.2017.1344346. Epub 2017 Oct 4.

7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features.

Author information

1
a Laboratoire de Biologie Moléculaire Eucaryote du CNRS, UMR5099, Centre de Biologie Intégrative, Université Paul Sabatier , Toulouse , France.
2
b Biological Research Centre , Hungarian Academy of Sciences , Szeged , Hungary.

Abstract

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes.

KEYWORDS:

7SK snRNA; 7SK snRNP; P-TEFb; RNA polymerase II pausing; transcription regulation

PMID:
28820318
PMCID:
PMC5834218
DOI:
10.1080/21541264.2017.1344346
[Indexed for MEDLINE]
Free PMC Article

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