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Arch Virol. 2017 Dec;162(12):3629-3637. doi: 10.1007/s00705-017-3529-4. Epub 2017 Aug 17.

Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico.

Author information

1
Instituto de Diagnóstico y Referencia Epidemiológicos "Dr. Manuel Martínez Báez" (InDRE), Secretaría de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, Mexico City, Mexico.
2
Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Casco de Santo Tomás, Miguel Hidalgo, 11340, Mexico City, Mexico.
3
Facultad de Ciencias, Unidad Académica de Ciencias y Tecnología UNAM, Parque Científico y Tecnológico de Yucatán, Carretera Mérida-Chuburná Puerto 31262, 97302, Mérida, Yucatán, Mexico.
4
Facultad de Medicina, Universidad Nacional Autónoma de México, Paseo de las Facultades S/N, Ciudad Universitaria, 04510, Mexico City, Mexico.
5
Instituto de Diagnóstico y Referencia Epidemiológicos "Dr. Manuel Martínez Báez" (InDRE), Secretaría de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, Mexico City, Mexico. ernesto.ramirez@salud.gob.mx.

Abstract

Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed. Phylogenetic analyses on the RNA sequences unveiled that the three atypical strains from Yucatan are associated with skunks. Analysis using the virus entire genome showed that they belong to a different lineage distinct from the variants described for this animal species in Mexico. The Chiapas atypical strain was grouped in a lineage that was considered extinct, while the others are clustered within classic dog variants.

PMID:
28819692
DOI:
10.1007/s00705-017-3529-4
[Indexed for MEDLINE]

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