Mechanisms of resistance to the BCR-ABL1 allosteric inhibitor asciminib

Leukemia. 2017 Dec;31(12):2844-2847. doi: 10.1038/leu.2017.264. Epub 2017 Aug 18.
No abstract available

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Proliferation / genetics
  • Drug Resistance, Neoplasm / drug effects*
  • Drug Resistance, Neoplasm / genetics
  • Fusion Proteins, bcr-abl / genetics
  • Humans
  • K562 Cells
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Niacinamide / analogs & derivatives*
  • Niacinamide / pharmacology
  • Protein Kinase Inhibitors / pharmacology*
  • Pyrazoles / pharmacology*

Substances

  • Protein Kinase Inhibitors
  • Pyrazoles
  • asciminib
  • Niacinamide
  • Fusion Proteins, bcr-abl